Infrared Spectral Microscopy As a Tool to Monitor Lung Fibrosis Development in a Model System

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2020 Oct 5

PMID 33014581

Citations 1

Authors

Vidyani Suryadevara

Shaiju S Nazeer

Hari Sreedhar

Oluwatobi Adelaja

Andre Kajdacsy-Balla

Viswanathan Natarajan

Michael J Walsh

Affiliations

Soon will be listed here.

Abstract

Tissue fibrosis is a progressive and destructive disease process that can occur in many different organs including the liver, kidney, skin, and lungs. Fibrosis is typically initiated by inflammation as a result of chronic insults such as infection, chemicals and autoimmune diseases. Current approaches to examine organ fibrosis are limited to radiological and histological analyses. Infrared spectroscopic imaging offers a potential alternative approach to gain insight into biochemical changes associated with fibrosis progression. In this study, we demonstrate that IR imaging of a mouse model of pulmonary fibrosis can identify biochemical changes observed with fibrosis progression and the beginning of resolution using K-means analysis, spectral ratios and multivariate data analysis. This study demonstrates that IR imaging may be a useful approach to understand the biochemical events associated with fibrosis initiation, progression and resolution for both the clinical setting and for assessing novel anti-fibrotic drugs in a model system.

Citing Articles

Characterization of Different Types of Epiretinal Proliferations by Synchrotron Radiation-Based Fourier Transform Infrared Micro-Spectroscopy.

Andjelic S, Kreuzer M, Hawlina M, Lumi X Int J Mol Sci. 2023; 24(5).

PMID: 36902265 PMC: 10003457. DOI: 10.3390/ijms24054834.

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