Minocycline in Treating Glioblastoma Multiforme: Far Beyond a Conventional Antibiotic

Overview

Journal J Oncol

Specialty Oncology

Date 2020 Oct 5

PMID 33014057

Citations 10

Authors

Amir R Afshari

Hamid Mollazadeh

Amirhossein Sahebkar

Affiliations

Soon will be listed here.

Abstract

One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM.

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