Circulating MicroRNAs: Biogenesis and Clinical Significance in Acute Myocardial Infarction

Overview

Journal Front Physiol

Date 2020 Oct 5

PMID 33013463

Citations 20

Authors

Lei Zhang

Han Ding

Yuan Zhang

Yin Wang

Wenjie Zhu

Peifeng Li

Affiliations

Soon will be listed here.

Abstract

Acute myocardial infarction (AMI) causes many deaths around the world. Early diagnosis can prevent the development of AMI and provide theoretical support for the subsequent treatment. miRNAs participate in the AMI pathological processes. We aim to determine the early diagnostic and the prognostic roles of circulating miRNAs in AMI in the existing studies and summarize all the data to provide a greater understanding of their utility for clinical application. We reviewed current knowledge focused on the AMI development and circulating miRNA formation. Meanwhile, we collected and analyzed the potential roles of circulating miRNAs in AMI diagnosis, prognosis and therapeutic strategies. Additionally, we elaborated on the challenges and clinical perspectives of the application of circulating miRNAs in AMI diagnosis. Circulating miRNAs are stable in the circulation and have earlier increases of circulating levels than diagnostic golden criteria. In addition, they are tissue and disease-specific. All these characteristics indicate that circulating miRNAs are promising biomarkers for the early diagnosis of AMI. Although there are several limitations to be resolved before clinical use, the application of circulating miRNAs shows great potential in the early diagnosis and the prognosis of AMI.

Citing Articles

Identification and validation of key genes associated with cell senescence in acute myocardial infarction.

Zhao W, Zhu G, Chu T, Wu L, Li H, Zhen Q Front Cardiovasc Med. 2025; 12:1499157.

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Circulating miRNA-21 as a diagnostic biomarker for acute coronary syndrome: a systematic review and meta-analysis of diagnostic test accuracy study.

He J, Li S, Wu X, Chen X, Yan D, Wang X Cardiovasc Diagn Ther. 2024; 14(3):328-339.

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Emerging Biomarkers of Acute Myocardial Infarction, An Overview of the Newest MicroRNAs.

Shahabi Raberi V, Javanshir E, Abbasnezhad M, Mashayekhi S, Abbasnezhad A, Ahmadzadeh M Galen Med J. 2024; 12:e2909.

PMID: 38774858 PMC: 11108668. DOI: 10.31661/gmj.v12i0.2909.

Circulating microRNAs in Cancer: A 5-Year Update with a Focus on Breast and Lung Cancers.

Siniscalco D, Galderisi U, Peluso G, Finicelli M Int J Mol Sci. 2024; 25(6).

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