As a Metabolic Silencer and Liver Tumor Suppressor

Overview

Journal Liver Res

Date 2020 Oct 2

PMID 33005474

Citations 13

Authors

Lijun Wang

Yu-Shiuan Wang

Eko Mugiyanto

Wei-Chiao Chang

Yu-Jui Yvonne Wan

Affiliations

Soon will be listed here.

Abstract

With obesity rate consistently increasing, a strong relationship between obesity and fatty liver disease has been discovered. More than 90% of bariatric surgery patients also have non-alcoholic fatty liver diseases (NAFLDs). NAFLD and non-alcoholic steatohepatitis (NASH), which are the hepatic manifestations of metabolic syndrome, can lead to liver carcinogenesis. Unfortunately, there is no effective medicine that can be used to treat NASH or liver cancer. Thus, it is critically important to understand the mechanism underlying the development of these diseases. Extensive evidence suggests that microRNA 22 () can be a diagnostic marker for liver diseases as well as a treatment target. This review paper focuses on the roles of in metabolism, steatosis, and liver carcinogenesis. Literature search is limited based on the publications included in the PubMed database in the recent 10 years.

Citing Articles

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The interregulatory circuit between non-coding RNA and apoptotic signaling in diabetic cardiomyopathy.

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Evaluation of the Relationship Between miRNA-22-3p and Gal-9 Levels in Glioblastoma.

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