Azithromycin and Glucosamine May Amplify the Type 1 Interferon Response to RNA Viruses in a Complementary Fashion

Overview

Journal Immunol Lett

Specialty Allergy & Immunology

Date 2020 Oct 1

PMID 33002511

Citations 3

Authors

James J DiNicolantonio

Jorge Barroso-Aranda

Mark F McCarty

Affiliations

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Abstract

Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP-N-acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction.

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References

Setnikar I, Pacini M, Revel L . Antiarthritic effects of glucosamine sulfate studied in animal models. Arzneimittelforschung. 1991; 41(5):542-5. View

Rossetti L, Hawkins M, Chen W, Gindi J, Barzilai N . In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. J Clin Invest. 1995; 96(1):132-40. PMC: 185181. DOI: 10.1172/JCI118013. View

Chuang K, Peng Y, Chien H, Lu M, Du H, Wu Y . Attenuation of LPS-induced lung inflammation by glucosamine in rats. Am J Respir Cell Mol Biol. 2013; 49(6):1110-9. DOI: 10.1165/rcmb.2013-0022OC. View

Bell G, Kantor E, Lampe J, Shen D, White E . Use of glucosamine and chondroitin in relation to mortality. Eur J Epidemiol. 2012; 27(8):593-603. PMC: 3557824. DOI: 10.1007/s10654-012-9714-6. View

Potempa L, Rajab I, Hart P, Bordon J, Fernandez-Botran R . Insights into the Use of C-Reactive Protein as a Diagnostic Index of Disease Severity in COVID-19 Infections. Am J Trop Med Hyg. 2020; 103(2):561-563. PMC: 7410479. DOI: 10.4269/ajtmh.20-0473. View

Sakata K, Nakayamada S, Miyazaki Y, Kubo S, Ishii A, Nakano K . Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus. Front Immunol. 2018; 9:1957. PMC: 6121190. DOI: 10.3389/fimmu.2018.01957. View

Celhar T, Magalhaes R, Fairhurst A . TLR7 and TLR9 in SLE: when sensing self goes wrong. Immunol Res. 2012; 53(1-3):58-77. DOI: 10.1007/s12026-012-8270-1. View

Peterson S, Hart G . New insights: A role for O-GlcNAcylation in diabetic complications. Crit Rev Biochem Mol Biol. 2016; 51(3):150-61. DOI: 10.3109/10409238.2015.1135102. View

Baron A, Zhu J, Zhu J, Weldon H, Maianu L, Garvey W . Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. J Clin Invest. 1995; 96(6):2792-801. PMC: 185989. DOI: 10.1172/JCI118349. View

10.

Sacre K, Criswell L, McCune J . Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther. 2012; 14(3):R155. PMC: 3446541. DOI: 10.1186/ar3895. View

11.

Pocobelli G, Kristal A, Patterson R, Potter J, Lampe J, Kolar A . Total mortality risk in relation to use of less-common dietary supplements. Am J Clin Nutr. 2010; 91(6):1791-800. PMC: 2869514. DOI: 10.3945/ajcn.2009.28639. View

12.

Katoh A, Kai H, Harada H, Niiyama H, Ikeda H . Oral Administration of Glucosamine Improves Vascular Endothelial Function by Modulating Intracellular Redox State. Int Heart J. 2017; 58(6):926-932. DOI: 10.1536/ihj.16-534. View

13.

Yuzwa S, Macauley M, Heinonen J, Shan X, Dennis R, He Y . A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 2008; 4(8):483-90. DOI: 10.1038/nchembio.96. View

14.

Gielen V, Johnston S, Edwards M . Azithromycin induces anti-viral responses in bronchial epithelial cells. Eur Respir J. 2010; 36(3):646-54. DOI: 10.1183/09031936.00095809. View

15.

Gao J, Huang X, Gu H, Lou L, Xu Z . Predictive criteria of severe cases in COVID-19 patients of early stage: A retrospective observational study. J Clin Lab Anal. 2020; 34(10):e23562. PMC: 7595922. DOI: 10.1002/jcla.23562. View

16.

Menzel M, Akbarshahi H, Tufvesson E, Persson C, Bjermer L, Uller L . Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017; 8(19):31601-31611. PMC: 5458233. DOI: 10.18632/oncotarget.16364. View

17.

Navarro S, White E, Kantor E, Zhang Y, Rho J, Song X . Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PLoS One. 2015; 10(2):e0117534. PMC: 4342228. DOI: 10.1371/journal.pone.0117534. View

18.

Schogler A, Kopf B, Edwards M, Johnston S, Casaulta C, Kieninger E . Novel antiviral properties of azithromycin in cystic fibrosis airway epithelial cells. Eur Respir J. 2014; 45(2):428-39. DOI: 10.1183/09031936.00102014. View

19.

Lagier J, Million M, Gautret P, Colson P, Cortaredona S, Giraud-Gatineau A . Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis. Travel Med Infect Dis. 2020; 36:101791. PMC: 7315163. DOI: 10.1016/j.tmaid.2020.101791. View

20.

Dostrovsky N, Towheed T, Hudson R, Anastassiades T . The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature. Osteoarthritis Cartilage. 2011; 19(4):375-80. DOI: 10.1016/j.joca.2011.01.007. View