Recent Endemic Coronavirus Infection is Associated with Less-severe COVID-19

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2020 Sep 30

PMID 32997649

Citations 219

Authors

Manish Sagar

Katherine Reifler

Michael Rossi

Nancy S Miller

Pranay Sinha

Laura F White

Joseph P Mizgerd

Affiliations

Soon will be listed here.

Abstract

Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.

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