Agitation and Impulsivity in Mid and Late Life As Possible Risk Markers for Incident Dementia

Overview

Journal Alzheimers Dement (N Y)

Date 2020 Sep 30

PMID 32995467

Citations 16

Authors

Daniel R Bateman

Sascha Gill

Sophie Hu

Erin D Foster

Myuri T Ruthirakuhan

Allis F Sellek

Moyra E Mortby

Veronika Matuskova

Kok Pin Ng

Rawan M Tarawneh

Yvonne Freund-Levi

Sanjeev Kumar

Serge Gauthier

Paul B Rosenberg

Fabricio Ferreira de Oliveira

D P Devanand

Clive Ballard

Zahinoor Ismail

Affiliations

Soon will be listed here.

Abstract

To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes (NPS) Professional Interest Area conducted a scoping review. Extending a series of reviews exploring the pre-dementia risk syndrome Mild Behavioral Impairment (MBI), we focused on late-onset agitation and impulsivity (the MBI impulse dyscontrol domain) and risk of incident cognitive decline and dementia. This scoping review of agitation and impulsivity pre-dementia syndromes summarizes the current biomedical literature in terms of epidemiology, diagnosis and measurement, neurobiology, neuroimaging, biomarkers, course and prognosis, treatment, and ongoing clinical trials. Validations for pre-dementia scales such as the MBI Checklist, and incorporation into longitudinal and intervention trials, are needed to better understand impulse dyscontrol as a risk factor for mild cognitive impairment and dementia.

Citing Articles

Social isolation increases impulsive choice with minor changes on metabolic function in middle-aged rats.

Venegas J, Weisz J, Choi C, Herringshaw R, Nabelsi O, Liang N Physiol Rep. 2025; 13(2):e70184.

PMID: 39821966 PMC: 11738651. DOI: 10.14814/phy2.70184.

Cognitive training of mice attenuates age-related decline in associative learning and behavioral flexibility.

Attalla D, Schatz A, Stumpenhorst K, Winter Y Front Behav Neurosci. 2024; 18:1326501.

PMID: 38549621 PMC: 10976437. DOI: 10.3389/fnbeh.2024.1326501.

Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment.

Naude J, Wang M, Leon R, Smith E, Ismail Z medRxiv. 2024; .

PMID: 38405711 PMC: 10888987. DOI: 10.1101/2024.02.11.24302665.

Cognitive trajectories in longitudinally trained 3xTg-AD mice.

Duggan M, Steinberg Z, Peterson T, Francois T, Parikh V Physiol Behav. 2023; 275:114435.

PMID: 38103626 PMC: 10872326. DOI: 10.1016/j.physbeh.2023.114435.

Predictors for quality of life in older adults: network analysis on cognitive and neuropsychiatric symptoms.

He C, Kong X, Li J, Wang X, Chen X, Wang Y BMC Geriatr. 2023; 23(1):850.

PMID: 38093173 PMC: 10720074. DOI: 10.1186/s12877-023-04462-4.

References

Bechara A, Van der Linden M . Decision-making and impulse control after frontal lobe injuries. Curr Opin Neurol. 2005; 18(6):734-9. DOI: 10.1097/01.wco.0000194141.56429.3c. View

Rosenberg P, Mielke M, Appleby B, Oh E, Geda Y, Lyketsos C . The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry. 2013; 21(7):685-95. PMC: 3428504. DOI: 10.1016/j.jagp.2013.01.006. View

Monastero R, Mangialasche F, Camarda C, Ercolani S, Camarda R . A systematic review of neuropsychiatric symptoms in mild cognitive impairment. J Alzheimers Dis. 2009; 18(1):11-30. DOI: 10.3233/JAD-2009-1120. View

Stacy M . Nonmotor symptoms in Parkinson's disease. Int J Neurosci. 2011; 121 Suppl 2:9-17. DOI: 10.3109/00207454.2011.620196. View

Cavanagh J, Wiecki T, Cohen M, Figueroa C, Samanta J, Sherman S . Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold. Nat Neurosci. 2011; 14(11):1462-7. PMC: 3394226. DOI: 10.1038/nn.2925. View

Ogama N, Sakurai T, Saji N, Nakai T, Niida S, Toba K . Frontal White Matter Hyperintensity Is Associated with Verbal Aggressiveness in Elderly Women with Alzheimer Disease and Amnestic Mild Cognitive Impairment. Dement Geriatr Cogn Dis Extra. 2018; 8(1):138-150. PMC: 5968270. DOI: 10.1159/000486826. View

Hu X, Uhle F, Fliessbach K, Wagner M, Han Y, Weber B . Reduced future-oriented decision making in individuals with subjective cognitive decline: A functional MRI study. Alzheimers Dement (Amst). 2017; 6:222-231. PMC: 5376255. DOI: 10.1016/j.dadm.2017.02.005. View

Jorm A, Butterworth P, Anstey K, Christensen H, Easteal S, Maller J . Memory complaints in a community sample aged 60-64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities. Psychol Med. 2005; 34(8):1495-506. DOI: 10.1017/s0033291704003162. View

Kales H, Kim H, Zivin K, Valenstein M, Seyfried L, Chiang C . Risk of mortality among individual antipsychotics in patients with dementia. Am J Psychiatry. 2011; 169(1):71-9. PMC: 4269551. DOI: 10.1176/appi.ajp.2011.11030347. View

10.

Isserles M, Daskalakis Z, Kumar S, Rajji T, Blumberger D . Clinical Effectiveness and Tolerability of Electroconvulsive Therapy in Patients with Neuropsychiatric Symptoms of Dementia. J Alzheimers Dis. 2017; 57(1):45-51. DOI: 10.3233/JAD-161000. View

11.

Zahodne L, Ornstein K, Cosentino S, Devanand D, Stern Y . Longitudinal relationships between Alzheimer disease progression and psychosis, depressed mood, and agitation/aggression. Am J Geriatr Psychiatry. 2013; 23(2):130-40. PMC: 3858495. DOI: 10.1016/j.jagp.2013.03.014. View

12.

Tahmasian M, Rochhausen L, Maier F, Williamson K, Drzezga A, Timmermann L . Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson's Disease. Front Behav Neurosci. 2015; 9:317. PMC: 4664667. DOI: 10.3389/fnbeh.2015.00317. View

13.

. [Facilitating nursing at home and in the nursing home]. Krankenpfl J. 2005; 43(1-3):34-5. View

14.

Ross J, McGonigle P, Van Bockstaele E . Locus Coeruleus, norepinephrine and Aβ peptides in Alzheimer's disease. Neurobiol Stress. 2015; 2:73-84. PMC: 4657149. DOI: 10.1016/j.ynstr.2015.09.002. View

15.

Biundo R, Weis L, Facchini S, Formento-Dojot P, Vallelunga A, Pilleri M . Patterns of cortical thickness associated with impulse control disorders in Parkinson's disease. Mov Disord. 2015; 30(5):688-95. DOI: 10.1002/mds.26154. View

16.

Imperiale F, Agosta F, Canu E, Markovic V, Inuggi A, Jecmenica-Lukic M . Brain structural and functional signatures of impulsive-compulsive behaviours in Parkinson's disease. Mol Psychiatry. 2017; 23(2):459-466. DOI: 10.1038/mp.2017.18. View

17.

Rosenberg P, Mielke M, Appleby B, Oh E, Leoutsakos J, Lyketsos C . Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int J Geriatr Psychiatry. 2010; 26(4):364-72. PMC: 3204866. DOI: 10.1002/gps.2535. View

18.

Borson S, Doane K . The impact of OBRA-87 on psychotropic drug prescribing in skilled nursing facilities. Psychiatr Serv. 1997; 48(10):1289-96. DOI: 10.1176/ps.48.10.1289. View

19.

Brodaty H, Arasaratnam C . Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry. 2012; 169(9):946-53. DOI: 10.1176/appi.ajp.2012.11101529. View

20.

Yudofsky S, Kopecky H, Kunik M, Silver J, Endicott J . The Overt Agitation Severity Scale for the objective rating of agitation. J Neuropsychiatry Clin Neurosci. 1998; 9(4):541-8. DOI: 10.1176/jnp.9.4.541. View