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Occurrence of SARS-CoV-2 in the Intraocular Milieu

Overview
Journal Exp Eye Res
Specialty Ophthalmology
Date 2020 Sep 29
PMID 32991885
Citations 10
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Abstract

The purpose of this research is to study the intraocular occurrence of SARS-CoV-2. In postmortem examinations, aqueous humor and the vitreous samples were collected. All individuals were previously positive in nasopharyngeal swabbing and cause of death was respiratory failure due to SARS-CoV-2 infection. Testing was done using quantitative RT-PCR. We included 16 aqueous humor and 16 vitreous samples for PCR testing. None of the results was positive for SARS-CoV-2. Human GAPDH genes to verify the presence of RNA was present in all aqueous humor samples (16/16, 100%) and 15/16 (93.8%) vitreous samples. In conclusion, this case series found no evidence of SARS-CoV-2 in the intraocular milieu.

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References
1.
Zhang X, Chen X, Chen L, Deng C, Zou X, Liu W . The evidence of SARS-CoV-2 infection on ocular surface. Ocul Surf. 2020; 18(3):360-362. PMC: 7194535. DOI: 10.1016/j.jtos.2020.03.010. View

2.
Senanayake P, Drazba J, Shadrach K, Milsted A, Rungger-Brandle E, Nishiyama K . Angiotensin II and its receptor subtypes in the human retina. Invest Ophthalmol Vis Sci. 2007; 48(7):3301-11. DOI: 10.1167/iovs.06-1024. View

3.
Qing H, Li Z, Yang Z, Shi M, Huang Z, Song J . The possibility of COVID-19 transmission from eye to nose. Acta Ophthalmol. 2020; 98(3):e388. PMC: 7228253. DOI: 10.1111/aos.14412. View

4.
Chen L, Liu M, Zhang Z, Qiao K, Huang T, Chen M . Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020; 104(6):748-751. PMC: 7211077. DOI: 10.1136/bjophthalmol-2020-316304. View

5.
Wan Y, Shang J, Graham R, Baric R, Li F . Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020; 94(7). PMC: 7081895. DOI: 10.1128/JVI.00127-20. View