Potential Immunomodulatory Activity of a Selected Strain H3-R2 As Evidenced and in Immunosuppressed Mice

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2020 Sep 28

PMID 32983062

Citations 12

Authors

Jiacui Shang

Feng Wan

Le Zhao

Xiangchen Meng

Bailiang Li

Affiliations

Soon will be listed here.

Abstract

The microbiota is directly involved in the development and modulation of the intestinal immune system. In particular, members of the genus play a primary role in immune regulation. In the present study, H3-R2 was screened from 15 bifidobacterium strains by experiment, showing a positive tolerance to digestive tract conditions, adhesion ability to intestinal epithelial cells and a regulatory effect on immune cell activity. Immunostimulatory activity of H3-R2 was also elucidated in cytoxan (CTX)-treated mice. The results showed that the administration of H3-R2 ameliorated the CTX-induced bodyweight loss and imbalanced expression of inflammatory cytokines, enhanced the production of secretory immunoglobulin A (SIgA), and promoted splenic lymphocyte proliferation, natural killer (NK) cell activity and phagocytosis of macrophages in immunosuppressed mice. In addition, H3-R2 restored injured intestinal mucosal, and increased the villus length and crypt depth in CTX-treated mice. The results could be helpful for understanding the functions of H3-R2, supporting its potential as a novel probiotic for immunoregulation.

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