Nucleophilic Synthesis of 6-l-[F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Sep 26

PMID 32977512

Citations 8

Authors

Raisa N Krasikova

Affiliations

Soon will be listed here.

Abstract

Positron emission tomography employing 6-l-[F]fluoro-3,4-dihydroxyphenylalanine (6-l-[F]FDOPA) is currently a highly relevant clinical tool for detection of gliomas, neuroendocrine tumors and evaluation of Parkinson's disease progression. Yet, the deficiencies of electrophilic synthesis of 6-l-[F]FDOPA hold back its wider use. To fulfill growing clinical demands for this radiotracer, novel synthetic strategies via direct nucleophilic F-radiloabeling starting from multi-Curie amounts of [F]fluoride, have been recently introduced. In particular, Cu-mediated radiofluorination of arylpinacol boronates and arylstannanes show significant promise for introduction into clinical practice. In this short review these current developments will be discussed with a focus on their applicability to automation.

Citing Articles

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Automation of Copper-Mediated F-Fluorination of Aryl Pinacol Boronates Using 4-Dimethylaminopyridinium Triflate.

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Experience of 6-l-[F]FDOPA Production Using Commercial Disposable Cassettes and an Automated Module.

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