Extracellular Vesicle-Dependent Cross-Talk in Cancer-Focus on Pancreatic Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Sep 25

PMID 32974169

Citations 12

Authors

Lise Nannan

Jean-Baptiste Oudart

Jean Claude Monboisse

Laurent Ramont

Sylvie Brassart-Pasco

Bertrand Brassart

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) like exosomes and shed microvesicles are generated by many different cells. However, among all the cells, cancer cells are now recognized to secrete more EVs than healthy cells. Tumor-derived EVs can be isolated from biofluids such as blood, urine, ascitic fluid, and saliva. Their numerous components (nucleic acids, proteins, and lipids) possess many pleiotropic functions involved in cancer progression. The tumor-derived EVs generated under the influence of tumor microenvironment play distant roles and promote cellular communication by directly interacting with different cells. Moreover, they modulate extracellular matrix remodeling and tumor progression. Tumor-derived EVs are involved in pre-metastatic niche formation, dependent on the EV-associated protein receptors, and in cancer chemoresistance as they transfer drug-resistance-related genes to recipient cells. Recent advances in preclinical and clinical fields suggest their potential use as biomarkers for diagnosis and prognosis as well as for drug delivery in cancer. In this Review, we discuss EV characteristics and pro-tumor capacities, and highlight the future crucial impact of tumor-derived EVs in pancreatic cancer diagnosis and prognosis.

Citing Articles

Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics.

Jackson Cullison S, Flemming J, Karagoz K, Wermuth P, Mahoney M J Extracell Biol. 2024; 3(11):e70017.

PMID: 39483807 PMC: 11522837. DOI: 10.1002/jex2.70017.

Exploring the Immunomodulatory Potential of Pancreatic Cancer-Derived Extracellular Vesicles through Proteomic and Functional Analyses.

Piro A, Cufaro M, Lanuti P, Brocco D, De Lellis L, Florio R Cancers (Basel). 2024; 16(10).

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The Role of Extracellular Vesicles in Metabolic Diseases.

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A Current Synopsis of the Emerging Role of Extracellular Vesicles and Micro-RNAs in Pancreatic Cancer: A Forward-Looking Plan for Diagnosis and Treatment.

Trifylli E, Kriebardis A, Koustas E, Papadopoulos N, Fortis S, Tzounakas V Int J Mol Sci. 2024; 25(6).

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Targeting tumor immunosuppressive microenvironment for pancreatic cancer immunotherapy: Current research and future perspective.

Li Y, Xiang S, Pan W, Wang J, Zhan H, Liu S Front Oncol. 2023; 13:1166860.

PMID: 37064113 PMC: 10090519. DOI: 10.3389/fonc.2023.1166860.

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