Computationally Designed 3D Printed Self-Expandable Polymer Stents with Biodegradation Capacity for Minimally Invasive Heart Valve Implantation: A Proof-of-Concept Study

Overview

Journal 3D Print Addit Manuf

Date 2020 Sep 21

PMID 32953940

Citations 16

Authors

Maria Sol Cabrera

Bart Sanders

Olga J G M Goor

Anita Driessen-Mol

Cees W J Oomens

Frank P T Baaijens

Affiliations

Soon will be listed here.

Abstract

The evolution of minimally invasive implantation procedures and the remodeling potential of decellularized tissue-engineered heart valves require stents with growth capacity to make these techniques available for pediatric patients. By means of computational tools and 3D printing technology, this proof-of-concept study demonstrates the design and manufacture of a polymer stent with a mechanical performance comparable to that of conventional nitinol stents used for heart valve implantation in animal trials. A commercially available 3D printing polymer was selected, and crush and crimping tests were conducted to validate the results predicted by the computational model. Finally, the degradability of the polymer was assessed via accelerated hydrolysis.

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