Antibacterial Activity of Gilg and Leaves Extracts Against Selected Bacteria

Overview

Journal Saudi J Med Med Sci

Specialty General Medicine

Date 2020 Sep 21

PMID 32952512

Authors

Hizkel Engiso

Teshale Worku

Dejen Nureye

Mohammed Salahaddin

Workineh Woldeselassie

Solomon Hambisa

Nymathullah Sharief

Affiliations

Soon will be listed here.

Abstract

Background: The increase in antimicrobial resistance worldwide has necessitated the search for alternative therapeutic agents. The leaf extracts of and have been used as traditional medicine for the management of eye, ear and wound infections in Ethiopia.

Objective: The objective of the study was to evaluate the antibacterial activity of and against three common bacteria.

Materials And Methods: In this experimental study, the antimicrobial properties of 80% methanol, chloroform and acetone extracts of and were evaluated against two Gram-positive bacteria ( ATCC 25923 and ATCC 49619) and one Gram-negative bacterium ( ATCC 25922) using the agar-well diffusion method. Ciprofloxacin 0.05 mg/disc was used as a positive control. Furthermore, a preliminary phytochemical study was carried out.

Results: The zones of inhibition shown by all extracts of the two plants against the tested bacteria were significantly lesser ( < 0.05) than the standard drug. and were the most susceptible strains for most extracts studied. The acetone extract of exhibited a higher inhibitory effect ( < 0.05) against (16 mm) and (19 mm) compared with its methanol extract. The chloroform extract of was more effective than its methanol extract ( < 0.05) against all tested bacteria. The acetone extract of displayed a higher inhibitory effect (20 mm) against than its methanol and chloroform extracts.

Conclusions: The leaf extracts of and exhibited broad-spectrum antimicrobial activity, highlighting their potential as phytotherapeutic drugs in preventing and treating infections caused by , and . Further investigations for isolating specific compounds and elucidating mechanisms are required to address the need for novel antibacterial drugs.

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