Synthesis of MOF-derived Ni@C Materials for the Electrochemical Detection of Histamine

Histamine (HA) plays an important role in food safety supervision and is also involved in various physiological functions. Accurate and rapid detection of HA in real sample is count for much as this is the significant prerequisite for its effective monitoring. In this study, we fabricated an electrochemical sensor to detect HA via the pyrolysis of the hydrothermal Ni-MOF (metal-organic frameworks), in which the obtained Ni@C material was deployed as the sensing agent. Ni@C was comprehensively characterized in terms of its morphology, constitution, as well as its electrochemical behavior. The as-prepared sensor (Ni@C/GCE) features excellent electrocatalytic activities. It was also observed that the electrochemical property of the sensor was substantially improved because Ni@C afforded an enlarged active surface and accelerated electron transport. This sensor affords amperometric analysis in the linear range of 10-100 μM HA with a 3.2 × 10 μM low detection limit (S/N = 3). Many important features, including decent anti-interference, reproducibility, stability, and reliability, were also observed. Importantly, the sensor enabled the measurement of HA in real samples obtained from fish, thus demonstrating its practical potential as a HA analytical detector.