Introduction of Mycobacterium Ulcerans Disease in the Bankim Health District of Cameroon Follows Damming of the Mapé River

Overview

Journal PLoS Negl Trop Dis

Specialties Infectious Diseases
Tropical Medicine

Date 2020 Sep 4

PMID 32886658

Citations 3

Authors

Koen Vandelannoote

Gerd Pluschke

Miriam Bolz

Martin W Bratschi

Sarah Kerber

Timothy P Stinear

Bouke C de Jong

Affiliations

Soon will be listed here.

Abstract

Buruli ulcer (BU) is an emerging ulcerative skin disease caused by infection with Mycobacterium ulcerans. Efforts to control its spread have been hampered by our limited understanding of M. ulcerans reservoirs and transmission, and the factors leading to the emergence of BU disease in a particular region. In this report we investigate an anecdotal link between damming the Mapé River in Cameroon and the emergence of BU in the Health Districts bordering Lake Bankim, the impoundment created by the Mapé dam. We used bacterial population genomics and molecular dating to find compelling support for a 2000 M. ulcerans introduction event that followed about 10 years after the filling of the newly created impoundment in 1988. We compared the genomic reconstructions with high-resolution satellite imagery to investigate what major environmental alterations might have driven the emergence of the new focus.

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