Recommendations for Pregnancy in Rare Inherited Anemias

Overview

Journal Hemasphere

Publisher Wiley

Specialty Hematology

Date 2020 Sep 5

PMID 32885142

Citations 3

Authors

Ali T Taher

Achille Iolascon

Charbel F Matar

Rayan Bou-Fakhredin

Lucia De Franceschi

Maria Domenica Cappellini

Wilma Barcellini

Roberta Russo

Immacolata Andolfo

Paul Tyan

Beatrice Gulbis

Yesim Aydinok

Nicholas P Anagnou

Gabriela Amstad Bencaiova

Hannah Tamary

Patricia Aguilar Martinez

Gianluca Forni

Raffaele Vindigni

Affiliations

Soon will be listed here.

Abstract

Rare inherited anemias are a subset of anemias caused by a genetic defect along one of the several stages of erythropoiesis or in different cellular components that affect red blood cell integrity, and thus its lifespan. Due to their low prevalence, several complications on growth and development, and multi-organ system damage are not yet well defined. Moreover, during the last decade there has been a lack of proper understanding of the impact of rare anemias on maternal and fetal outcomes. In addition, there are no clear-cut guidelines outlining the pathophysiological trends and management options unique to this special population. Here, we present on behalf of the European Hematology Association, evidence- and consensus-based guidelines, established by an international group of experts in different fields, including hematologists, gynecologists, general practitioners, medical geneticists, and experts in rare inherited anemias from various European countries for standardized and appropriate choice of therapeutic interventions for the management of pregnancy in rare inherited anemias, including Diamond-Blackfan Anemia, Congenital Dyserythropoietic Anemias, Thalassemia, Sickle Cell Disease, Enzyme deficiency and Red cell membrane disorders.

Citing Articles

Thalassemias and Sickle Cell Diseases in Pregnancy: SITE Good Practice.

Pinto V, Cima R, Di Maggio R, Alga M, Gigante A, Longo F J Clin Med. 2025; 14(3).

PMID: 39941620 PMC: 11818879. DOI: 10.3390/jcm14030948.

Hematologic Complications of Pregnancy.

Patel P, Patel N, Hedges M, Benson A, Tomer A, Lo J Eur J Haematol. 2025; 114(4):596-614.

PMID: 39790057 PMC: 11882378. DOI: 10.1111/ejh.14372.

Managing sickle cell disease and related complications in pregnancy: results of an international Delphi panel.

Sharma D, Kozanoglu I, Ataga K, Benachi A, Buyukkurt S, Lanzkron S Blood Adv. 2024; 8(4):1018-1029.

PMID: 38206762 PMC: 10879679. DOI: 10.1182/bloodadvances.2023011301.

Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms.

Sangkhae V, Fisher A, Ganz T, Nemeth E Annu Rev Nutr. 2023; 43:279-300.

PMID: 37253681 PMC: 10723031. DOI: 10.1146/annurev-nutr-061021-030404.

Successful outcome in a compound heterozygote haemoglobin E/beta-thalassaemia in pregnancy.

Dubey K, Sharma C, Shet S, Shekhar S BMJ Case Rep. 2023; 16(2).

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