ABHD4-dependent Developmental Anoikis Safeguards the Embryonic Brain

Overview

Journal Nat Commun

Specialty Biology

Date 2020 Sep 2

PMID 32868797

Citations 15

Authors

Zsofia I Laszlo

Zsolt Lele

Miklos Zoldi

Vivien Miczan

Fruzsina Mogor

Gabriel M Simon

Ken Mackie

Imre Kacskovics

Benjamin F Cravatt

Istvan Katona

Affiliations

Soon will be listed here.

Abstract

A specialized neurogenic niche along the ventricles accumulates millions of progenitor cells in the developing brain. After mitosis, fate-committed daughter cells delaminate from this germinative zone. Considering the high number of cell divisions and delaminations taking place during embryonic development, brain malformations caused by ectopic proliferation of misplaced progenitor cells are relatively rare. Here, we report that a process we term developmental anoikis distinguishes the pathological detachment of progenitor cells from the normal delamination of daughter neuroblasts in the developing mouse neocortex. We identify the endocannabinoid-metabolizing enzyme abhydrolase domain containing 4 (ABHD4) as an essential mediator for the elimination of pathologically detached cells. Consequently, rapid ABHD4 downregulation is necessary for delaminated daughter neuroblasts to escape from anoikis. Moreover, ABHD4 is required for fetal alcohol-induced apoptosis, but not for the well-established form of developmentally controlled programmed cell death. These results suggest that ABHD4-mediated developmental anoikis specifically protects the embryonic brain from the consequences of sporadic delamination errors and teratogenic insults.

Citing Articles

Differential effects of prenatal alcohol exposure on brain growth reveals early upregulation of cell cycle and apoptosis and delayed downregulation of metabolism in affected offspring.

Sambo D, Kinstler E, Lin Y, Goldman D PLoS One. 2024; 19(11):e0311683.

PMID: 39602444 PMC: 11602053. DOI: 10.1371/journal.pone.0311683.

Anoikis in cell fate, physiopathology, and therapeutic interventions.

Mei J, Jiang X, Tian H, Rong D, Song J, Wang L MedComm (2020). 2024; 5(10):e718.

PMID: 39286778 PMC: 11401975. DOI: 10.1002/mco2.718.

Presynaptic nanoscale components of retrograde synaptic signaling.

Barti B, Dudok B, Kenesei K, Zoldi M, Miczan V, Balla G Sci Adv. 2024; 10(22):eado0077.

PMID: 38809980 PMC: 11135421. DOI: 10.1126/sciadv.ado0077.

Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders.

Hwang H, Yamashita S, Matsumoto Y, Ito M, Edwards A, Sasaki J Mol Psychiatry. 2024; 29(11):3364-3380.

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Identification and validation of a novel anoikis-related prognostic model for prostate cancer.

Zhang P, Lv W, Luan Y, Cai W, Min X, Feng Z Mol Genet Genomic Med. 2024; 12(4):e2419.

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