Cefiderocol Resistance in Acinetobacter Baumannii: Roles of β-Lactamases, Siderophore Receptors, and Penicillin Binding Protein 3

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2020 Sep 2

PMID 32868330

Citations 64

Authors

Saquib Malik

Monica Kaminski

David Landman

John Quale

Affiliations

Soon will be listed here.

Abstract

Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 strains with cefiderocol MICs ranging from ≤0.03 to >32 μg/ml. Cefiderocol resistance could not be explained by β-lactamase activity. Cefiderocol resistance was associated with reduced expression of the siderophore receptor gene Mutations involving PBP3 may have contributed to resistance in one strain. Additional studies are needed to assess the role of other siderophore receptors.

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