Cyclotron Production of PET Radiometals in Liquid Targets: Aspects and Prospects

Overview

Journal Curr Radiopharm

Publisher Bentham Science Publishers

Specialties Nuclear Medicine
Pharmacology
Radiology

Date 2020 Sep 2

PMID 32867656

Citations 10

Authors

Mukesh K Pandey

Timothy R DeGrado

Affiliations

Soon will be listed here.

Abstract

The present review describes the methodological aspects and prospects of the production of Positron Emission Tomography (PET) radiometals in a liquid target using low-medium energy medical cyclotrons. The main objective of this review is to delineate and discuss the critical factors involved in the liquid target production of radiometals, including type of salt solution, solution composition, beam energy, beam current, the effect of irradiation duration (length of irradiation) and challenges posed by in-target chemistry in relation with irradiation parameters. We also summarize the optimal parameters for the production of various radiometals in liquid targets. Additionally, we discuss the future prospects of PET radiometals production in the liquid targets for academic research and clinical applications. Significant emphasis has been given to the production of Ga using liquid targets due to the growing demand for Ga labeled PSMA vectors, [Ga]- Ga-DOTATATE, [Ga]Ga-DOTANOC and some upcoming Ga labeled radiopharmaceuticals. Other PET radiometals included in the discussion are Y, Zn and Zr.

Citing Articles

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Optimised production of technetium-94m for PET imaging by proton-irradiation of phosphomolybdic acid in cyclotron liquid target.

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Recovery of Gallium-68 and Zinc from HNO-Based Solution by Liquid-Liquid Extraction with Arylamino Phosphonates.

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References

Bansal A, Pandey M, Yamada S, Goyal R, Schmit N, Jeon R . [Zr]Zr-DBN labeled cardiopoietic stem cells proficient for heart failure. Nucl Med Biol. 2020; 90-91:23-30. PMC: 7736260. DOI: 10.1016/j.nucmedbio.2020.09.001. View

Yoo J, Tang L, Perkins T, Rowland D, Laforest R, Lewis J . Preparation of high specific activity (86)Y using a small biomedical cyclotron. Nucl Med Biol. 2005; 32(8):891-7. DOI: 10.1016/j.nucmedbio.2005.06.007. View

Yang B, Brahmbhatt A, Torres E, Thielen B, McCall D, Engel S . Tracking and Therapeutic Value of Human Adipose Tissue-derived Mesenchymal Stem Cell Transplantation in Reducing Venous Neointimal Hyperplasia Associated with Arteriovenous Fistula. Radiology. 2015; 279(2):513-22. PMC: 4836988. DOI: 10.1148/radiol.2015150947. View

Biddlecombe G, Rogers B, de Visser M, Parry J, de Jong M, Erion J . Molecular imaging of gastrin-releasing peptide receptor-positive tumors in mice using 64Cu- and 86Y-DOTA-(Pro1,Tyr4)-bombesin(1-14). Bioconjug Chem. 2007; 18(3):724-30. DOI: 10.1021/bc060281l. View

Pandey M, Byrne J, Schlasner K, Schmit N, DeGrado T . Cyclotron production of Ga in a liquid target: Effects of solution composition and irradiation parameters. Nucl Med Biol. 2019; 74-75:49-55. DOI: 10.1016/j.nucmedbio.2019.03.002. View

Synowiecki M, Perk L, Nijsen J . Production of novel diagnostic radionuclides in small medical cyclotrons. EJNMMI Radiopharm Chem. 2018; 3(1):3. PMC: 5824710. DOI: 10.1186/s41181-018-0038-z. View

Yakabuskie P, Joseph J, Stuart C, Wren J . Long-term γ-radiolysis kinetics of NO3(-) and NO2(-) solutions. J Phys Chem A. 2011; 115(17):4270-8. DOI: 10.1021/jp200262c. View

DeGrado T, Kemp B, Pandey M, Jiang H, Gunderson T, Linscheid L . First PET Imaging Studies With 63Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease. Mol Imaging. 2016; 15. PMC: 5469518. DOI: 10.1177/1536012116673793. View

Bansal A, Pandey M, Demirhan Y, Nesbitt J, Crespo-Diaz R, Terzic A . Novel (89)Zr cell labeling approach for PET-based cell trafficking studies. EJNMMI Res. 2015; 5:19. PMC: 4401478. DOI: 10.1186/s13550-015-0098-y. View

10.

Barnham K, Bush A . Biological metals and metal-targeting compounds in major neurodegenerative diseases. Chem Soc Rev. 2014; 43(19):6727-49. DOI: 10.1039/c4cs00138a. View

11.

Lukic D, Tamburella C, Buchegger F, Beyer G, Comor J, Seimbille Y . High efficiency production and purification of 86Y based on electrochemical separation. Appl Radiat Isot. 2009; 67(4):523-9. DOI: 10.1016/j.apradiso.2008.12.008. View

12.

Lin M, Waligorski G, Lepera C . Production of curie quantities of Ga with a medical cyclotron via the Zn(p,n)Ga reaction. Appl Radiat Isot. 2017; 133:1-3. DOI: 10.1016/j.apradiso.2017.12.010. View

13.

Hoehr C, Morley T, Buckley K, Trinczek M, Hanemaayer V, Schaffer P . Radiometals from liquid targets: 94mTc production using a standard water target on a 13 MeV cyclotron. Appl Radiat Isot. 2012; 70(10):2308-12. DOI: 10.1016/j.apradiso.2012.06.004. View

14.

Riga S, Cicoria G, Pancaldi D, Zagni F, Vichi S, Dassenno M . Production of Ga-68 with a General Electric PETtrace cyclotron by liquid target. Phys Med. 2018; 55:116-126. DOI: 10.1016/j.ejmp.2018.10.018. View

15.

Huang J, Cui L, Wang F, Liu Z . PET tracers based on (86)Y. Curr Radiopharm. 2011; 4(2):122-30. DOI: 10.2174/1874471011104020122. View

16.

Roohani N, Hurrell R, Kelishadi R, Schulin R . Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013; 18(2):144-57. PMC: 3724376. View

17.

DeGrado T, Pandey M, Byrne J, Engelbrecht H, Jiang H, Packard A . Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc. J Nucl Med. 2014; 55(8):1348-54. DOI: 10.2967/jnumed.114.141218. View

18.

Oehlke E, Hoehr C, Hou X, Hanemaayer V, Zeisler S, Adam M . Production of Y-86 and other radiometals for research purposes using a solution target system. Nucl Med Biol. 2015; 42(11):842-9. DOI: 10.1016/j.nucmedbio.2015.06.005. View

19.

Pandey M, Byrne J, Jiang H, Packard A, DeGrado T . Cyclotron production of (68)Ga via the (68)Zn(p,n)(68)Ga reaction in aqueous solution. Am J Nucl Med Mol Imaging. 2014; 4(4):303-10. PMC: 4074496. View

20.

Nayak T, Garmestani K, Baidoo K, Milenic D, Brechbiel M . Preparation, biological evaluation, and pharmacokinetics of the human anti-HER1 monoclonal antibody panitumumab labeled with 86Y for quantitative PET of carcinoma. J Nucl Med. 2010; 51(6):942-50. PMC: 2892806. DOI: 10.2967/jnumed.109.071290. View