Role of Melatonin in the Synchronization of Asexual Forms in the Parasite

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2020 Sep 2

PMID 32867164

Citations 6

Authors

Maneesh Kumar Singh

Barbara Karina de Menezes Dias

Celia R S Garcia

Affiliations

Soon will be listed here.

Abstract

The indoleamine compound melatonin has been extensively studied in the regulation of the circadian rhythm in nearly all vertebrates. The effects of melatonin have also been studied in Protozoan parasites, especially in the synchronization of the human malaria parasite via a complex downstream signalling pathway. Melatonin activates protein kinase A (PfPKA) and requires the activation of protein kinase 7 (PfPK7), PLC-IP, and a subset of genes from the ubiquitin-proteasome system. In other parasites, such as and , melatonin increases inflammatory components, thus amplifying the protective response of the host's immune system and affecting parasite load. The development of melatonin-related indole compounds exhibiting antiparasitic properties clearly suggests this new and effective approach as an alternative treatment. Therefore, it is critical to understand how melatonin confers stimulatory functions in host-parasite biology.

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