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Toward an Understanding of the Pathophysiology of Chronic Laryngitis

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Abstract

Chronic laryngitis, characterized by inflammation of the laryngeal tissues, is the most commonly diagnosed organic voice disorder, yet treatments targeting suspected etiologic factors have demonstrated limited efficacy. A major barrier to the development of improved medical therapies for chronic laryngitis is a fundamental gap in knowledge related to the pathophysiology of laryngeal inflammation. This article provides a review of the literature specific to laryngeal immunity in health and disease.

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References
1.
Gorti G, Birchall M, Haverson K, Macchiarini P, Bailey M . A preclinical model for laryngeal transplantation: anatomy and mucosal immunology of the porcine larynx. Transplantation. 1999; 68(11):1638-42. DOI: 10.1097/00007890-199912150-00006. View

2.
Nascimbeni M, Shin E, Chiriboga L, Kleiner D, Rehermann B . Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood. 2004; 104(2):478-86. DOI: 10.1182/blood-2003-12-4395. View

3.
Cherry J, SIEGEL C, MARGULIES S, Donner M . Pharyngeal localization of symptoms of gastroesophageal reflux. Ann Otol Rhinol Laryngol. 1970; 79(5):912-4. DOI: 10.1177/000348947007900506. View

4.
Borkowski G, Sudhoff H, Koslowski F, Hackstedt G, Radu H, Luckhaupt H . A possible role of Helicobacter pylori infection in the etiology of chronic laryngitis. Eur Arch Otorhinolaryngol. 1997; 254(9-10):481-2. DOI: 10.1007/BF02439987. View

5.
Sopori M . Effects of cigarette smoke on the immune system. Nat Rev Immunol. 2002; 2(5):372-7. DOI: 10.1038/nri803. View