Prevention Strategies of Mother-to-child Transmission of Hepatitis B Virus (HBV) Infection

Overview

Journal Pediatr Investig

Specialty Pediatrics

Date 2020 Aug 28

PMID 32851357

Citations 13

Authors

Yao Hu

Hui Yu

Affiliations

Soon will be listed here.

Abstract

Chronic hepatitis B virus (HBV) infection caused by mother-to-child transmission (MTCT, also known as vertical transmission) during the perinatal period is a major public health problem worldwide. Despite the availability of the combined active-passive immunization with a hepatitis B vaccine and hepatitis B immunoglobulin after birth, about 9% of newborns are still infected with HBV, especially those born to hepatitis B e antigen (HBeAg)-positive mothers. Currently, the management of HBV infection during pregnancy remains controversial. This article briefly reviews the recent advances in the epidemiology of HBV, immunization against it, and management strategies in the third trimester.

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