Advances in the Application of Supramolecular Hydrogels for Stem Cell Delivery and Cartilage Tissue Engineering

Overview

Journal Front Bioeng Biotechnol

Date 2020 Aug 28

PMID 32850718

Citations 16

Authors

Xin Yan

You-Rong Chen

Yi-Fan Song

Jing Ye

Meng Yang

Bing-Bing Xu

Ji-Ying Zhang

Xing Wang

Jia-Kuo Yu

Affiliations

Soon will be listed here.

Abstract

Cartilage defects pose a great threat to the health of the aging population. Cartilage has limited self-regeneration ability because it lacks blood vessels, nerves and lymph. To achieve efficient cartilage regeneration, supramolecular hydrogels are used in medical applications and tissue engineering as they are tunable and reversible in nature. Moreover, they possess supramolecular interactions which allow the incorporation of cells. These hydrogels present great potential for tissue engineering-based therapies. This review presents advances in the development of stem cell-laden supramolecular hydrogels. We discuss new possibilities for stem cell therapy and their uses in cartilage tissue engineering. Gray areas and future perspectives are discussed.

Citing Articles

A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials.

Choi H, Choi W, Jeong J Gels. 2024; 10(11).

PMID: 39590049 PMC: 11594258. DOI: 10.3390/gels10110693.

Cartilage defect repair in a rat model via a nanocomposite hydrogel loaded with melatonin-loaded gelatin nanofibers and menstrual blood stem cells: an in vitro and in vivo study.

Yuan L, Yao L, Ren X, Chen X, Li X, Xu Y J Mater Sci Mater Med. 2024; 35(1):55.

PMID: 39347832 PMC: 11442572. DOI: 10.1007/s10856-024-06820-z.

Fluoride-Ion-Responsive Sol-Gel Transition in an L-Cysteine/AgNO System: Self-Assembly Peculiarities and Anticancer Activity.

Vishnevetskii D, Andrianova Y, Polyakova E, Ivanova A, Mekhtiev A Gels. 2024; 10(5).

PMID: 38786249 PMC: 11121661. DOI: 10.3390/gels10050332.

Effect of Peptide-Polymer Host-Guest Electrostatic Interactions on Self-Assembling Peptide Hydrogels Structural and Mechanical Properties and Polymer Diffusivity.

Dong S, Chapman S, Pluen A, Richardson S, Miller A, Saiani A Biomacromolecules. 2024; 25(6):3628-3641.

PMID: 38771115 PMC: 11170954. DOI: 10.1021/acs.biomac.4c00232.

A review of advanced hydrogels for cartilage tissue engineering.

Ansari M, Darvishi A, Sabzevari A Front Bioeng Biotechnol. 2024; 12:1340893.

PMID: 38390359 PMC: 10881834. DOI: 10.3389/fbioe.2024.1340893.

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