Next Generation Influenza Vaccines: Looking into the Crystal Ball
Overview
Authors
Affiliations
Influenza infections are responsible for significant number of deaths and overwhelming costs worldwide every year. Vaccination represents the only cost-efficient alternative to address this major problem in human health. However, current vaccines are fraught by many limitations, being far from optimal. Among them, the need to upgrade vaccines every year through a time-consuming process open to different caveats, and the critical fact that they exhibit poorer efficacy in individuals who are at high risk for severe infections. Where are we? How can knowledge and technologies contribute towards removing current roadblocks? What does the future offer in terms of next generation vaccines?
The applications of live attenuated influenza a virus with modified NS1 gene.
Zhang H, Wang L, An Y, Chen Z Mol Ther Nucleic Acids. 2025; 36(1):102471.
PMID: 40046952 PMC: 11880705. DOI: 10.1016/j.omtn.2025.102471.
Allen J, Zhang X, Medina J, Thomas M, Lynch A, Nelson R Vaccines (Basel). 2025; 12(12.
PMID: 39772026 PMC: 11679666. DOI: 10.3390/vaccines12121364.
Carlock M, Allen J, Hanley H, Ross T PLoS One. 2024; 19(6):e0301157.
PMID: 38917104 PMC: 11198804. DOI: 10.1371/journal.pone.0301157.
Allen J, Ross T Front Immunol. 2024; 15:1334670.
PMID: 38533508 PMC: 10963417. DOI: 10.3389/fimmu.2024.1334670.
Allen J, Ross T J Virol. 2022; 96(7):e0165221.
PMID: 35289635 PMC: 9006891. DOI: 10.1128/jvi.01652-21.