Immune History and Influenza Vaccine Effectiveness

Overview

Journal Vaccines (Basel)

Date 2018 Jun 9

PMID 29883414

Citations 114

Authors

Joseph A Lewnard

Sarah Cobey

Affiliations

Soon will be listed here.

Abstract

The imperfect effectiveness of seasonal influenza vaccines is often blamed on antigenic mismatch, but even when the match appears good, effectiveness can be surprisingly low. Seasonal influenza vaccines also stand out for their variable effectiveness by age group from year to year and by recent vaccination status. These patterns suggest a role for immune history in influenza vaccine effectiveness, but inference is complicated by uncertainty about the contributions of bias to the estimates themselves. In this review, we describe unexpected patterns in the effectiveness of seasonal influenza vaccination and explain how these patterns might arise as consequences of study design, the dynamics of immune memory, or both. Resolving this uncertainty could lead to improvements in vaccination strategy, including the use of universal vaccines in experienced populations, and the evaluation of vaccine efficacy against influenza and other antigenically variable pathogens.

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References

Sullivan S, Tchetgen Tchetgen E, Cowling B . Theoretical Basis of the Test-Negative Study Design for Assessment of Influenza Vaccine Effectiveness. Am J Epidemiol. 2016; 184(5):345-53. PMC: 5013887. DOI: 10.1093/aje/kww064. View

Foppa I, Ferdinands J, Chaves S, Haber M, Reynolds S, Flannery B . The case test-negative design for studies of the effectiveness of influenza vaccine in inpatient settings. Int J Epidemiol. 2016; 45(6):2052-2059. PMC: 5025336. DOI: 10.1093/ije/dyw022. View

Foppa I, Haber M, Ferdinands J, Shay D . The case test-negative design for studies of the effectiveness of influenza vaccine. Vaccine. 2013; 31(30):3104-9. DOI: 10.1016/j.vaccine.2013.04.026. View

McCarthy K, Watanabe A, Kuraoka M, Do K, McGee C, Sempowski G . Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity. 2018; 48(1):174-184.e9. PMC: 5810956. DOI: 10.1016/j.immuni.2017.12.009. View

Young B, Sadarangani S, Jiang L, Wilder-Smith A, Chen M . Duration of Influenza Vaccine Effectiveness: A Systematic Review, Meta-analysis, and Meta-regression of Test-Negative Design Case-Control Studies. J Infect Dis. 2017; 217(5):731-741. DOI: 10.1093/infdis/jix632. View

Erbelding E, Post D, Stemmy E, Roberts P, Augustine A, Ferguson S . A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases. J Infect Dis. 2018; 218(3):347-354. PMC: 6279170. DOI: 10.1093/infdis/jiy103. View

Simonsen L, Reichert T, Viboud C, Blackwelder W, Taylor R, Miller M . Impact of influenza vaccination on seasonal mortality in the US elderly population. Arch Intern Med. 2005; 165(3):265-72. DOI: 10.1001/archinte.165.3.265. View

Demicheli V, Jefferson T, Di Pietrantonj C, Ferroni E, Thorning S, Thomas R . Vaccines for preventing influenza in the elderly. Cochrane Database Syst Rev. 2018; 2:CD004876. PMC: 6491101. DOI: 10.1002/14651858.CD004876.pub4. View

Ohmit S, Petrie J, Malosh R, Cowling B, Thompson M, Shay D . Influenza vaccine effectiveness in the community and the household. Clin Infect Dis. 2013; 56(10):1363-9. PMC: 3693492. DOI: 10.1093/cid/cit060. View

10.

Saito N, Komori K, Suzuki M, Kishikawa T, Yasaka T, Ariyoshi K . Dose-Dependent Negative Effects of Prior Multiple Vaccinations Against Influenza A and Influenza B Among Schoolchildren: A Study of Kamigoto Island in Japan During the 2011-2012, 2012-2013, and 2013-2014 Influenza Seasons. Clin Infect Dis. 2018; 67(6):897-904. DOI: 10.1093/cid/ciy202. View

11.

Westreich D, Hudgens M . Invited Commentary: Beware the Test-Negative Design. Am J Epidemiol. 2016; 184(5):354-6. PMC: 5013886. DOI: 10.1093/aje/kww063. View

12.

Ndifon W . A simple mechanistic explanation for original antigenic sin and its alleviation by adjuvants. J R Soc Interface. 2015; 12(112). PMC: 4685838. DOI: 10.1098/rsif.2015.0627. View

13.

Miller M, Gardner T, Krammer F, Aguado L, Tortorella D, Basler C . Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Sci Transl Med. 2013; 5(198):198ra107. PMC: 4091683. DOI: 10.1126/scitranslmed.3006637. View

14.

Belongia E, Simpson M, King J, Sundaram M, Kelley N, Osterholm M . Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies. Lancet Infect Dis. 2016; 16(8):942-51. DOI: 10.1016/S1473-3099(16)00129-8. View

15.

Petrie J, Ohmit S, Cheng C, Martin E, Malosh R, Lauring A . Influenza Vaccine Effectiveness Against Antigenically Drifted Influenza Higher Than Expected in Hospitalized Adults: 2014-2015. Clin Infect Dis. 2016; 63(8):1017-25. DOI: 10.1093/cid/ciw432. View

16.

Shi M, An Q, Ainslie K, Haber M, Orenstein W . A comparison of the test-negative and the traditional case-control study designs for estimation of influenza vaccine effectiveness under nonrandom vaccination. BMC Infect Dis. 2017; 17(1):757. PMC: 5721721. DOI: 10.1186/s12879-017-2838-2. View

17.

Lessler J, Riley S, Read J, Wang S, Zhu H, Smith G . Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China. PLoS Pathog. 2012; 8(7):e1002802. PMC: 3400560. DOI: 10.1371/journal.ppat.1002802. View

18.

Goodwin K, Viboud C, Simonsen L . Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine. 2005; 24(8):1159-69. DOI: 10.1016/j.vaccine.2005.08.105. View

19.

Cai F, Fussell T, Cobey S, Lipsitch M . Use of an individual-based model of pneumococcal carriage for planning a randomized trial of a whole-cell vaccine. PLoS Comput Biol. 2018; 14(10):e1006333. PMC: 6181404. DOI: 10.1371/journal.pcbi.1006333. View

20.

Broome C, Facklam R, Fraser D . Pneumococcal disease after pneumococcal vaccination: an alternative method to estimate the efficacy of pneumococcal vaccine. N Engl J Med. 1980; 303(10):549-52. DOI: 10.1056/NEJM198009043031003. View