» Articles » PMID: 32822217

Solving the Riddle: Targeting the Imbalance of Sphingolipids in Asthma to Oppose Airway Hyperresponsiveness

Overview
Date 2020 Aug 22
PMID 32822217
Citations 5
Authors
Affiliations
Soon will be listed here.
Citing Articles

Lipids in Equine Airway Inflammation: An Overview of Current Knowledge.

Monki J, Mykkanen A Animals (Basel). 2024; 14(12).

PMID: 38929431 PMC: 11200544. DOI: 10.3390/ani14121812.


Metabolic Contributions to Pathobiology of Asthma.

Roshan Lal T, Cechinel L, Freishtat R, Rastogi D Metabolites. 2023; 13(2).

PMID: 36837831 PMC: 9962059. DOI: 10.3390/metabo13020212.


Sphingolipids and Asthma.

Worgall T Adv Exp Med Biol. 2022; 1372:145-155.

PMID: 35503179 DOI: 10.1007/978-981-19-0394-6_10.


Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.

Wasserman E, Worgall S Mol Cell Pediatr. 2021; 8(1):22.

PMID: 34931265 PMC: 8688659. DOI: 10.1186/s40348-021-00130-y.


Update in Adult Asthma 2020.

Halayko A, Pascoe C, Gereige J, Peters M, Cohen R, Woodruff P Am J Respir Crit Care Med. 2021; 204(4):395-402.

PMID: 34181860 PMC: 8759264. DOI: 10.1164/rccm.202103-0552UP.

References
1.
Rosenfeldt H, Amrani Y, Watterson K, Murthy K, Panettieri Jr R, Spiegel S . Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB J. 2003; 17(13):1789-99. DOI: 10.1096/fj.02-0836com. View

2.
Kim S, Jung H, Kim M, Moon J, Ban G, Kim S . Ceramide/sphingosine-1-phosphate imbalance is associated with distinct inflammatory phenotypes of uncontrolled asthma. Allergy. 2020; 75(8):1991-2004. DOI: 10.1111/all.14236. View

3.
Worgall T, Veerappan A, Sung B, Kim B, Weiner E, Bholah R . Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity. Sci Transl Med. 2013; 5(186):186ra67. DOI: 10.1126/scitranslmed.3005765. View

4.
James B, Milstien S, Spiegel S . ORMDL3 and allergic asthma: From physiology to pathology. J Allergy Clin Immunol. 2019; 144(3):634-640. PMC: 6910079. DOI: 10.1016/j.jaci.2019.07.023. View

5.
Moffatt M, Kabesch M, Liang L, Dixon A, Strachan D, Heath S . Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007; 448(7152):470-3. DOI: 10.1038/nature06014. View