Minimally Invasive Glaucoma Surgery: What Do We Know? Where Should We Go?

Overview

Journal Transl Vis Sci Technol

Specialties Biomedical Engineering
Ophthalmology

Date 2020 Aug 22

PMID 32821487

Citations 6

Authors

Chen Xin

Huangzhou Wang

Ningli Wang

Affiliations

Soon will be listed here.

Abstract

With the arrival of a plethora of new and revolving minimally invasive glaucoma surgery techniques, glaucoma specialists currently are fortunate to have various surgical options that aim to recovery of the function of the aqueous outflow system in different ways. Meanwhile, the aqueous outflow system has become the hot point of researching. In ARVO 2019, a special interest group session was held on new perspectives on minimally invasive glaucoma surgery. Ten surgeons, clinical professors, and experimental scientists were invited to report their latest studies and discussed on five hot topics in this special interest group. This review summarizes the special interest group session and posts the issues of greatest concern, providing insight to the aqueous outflow system and areas that require further study.

Citing Articles

Recent Advancements in Glaucoma Surgery-A Review.

Ang B, Lim S, Betzler B, Wong H, Stewart M, Dorairaj S Bioengineering (Basel). 2023; 10(9).

PMID: 37760198 PMC: 10525614. DOI: 10.3390/bioengineering10091096.

[Minimally invasive glaucoma surgery-Comparison of angle based procedures].

Klabe K, Rufer F Ophthalmologie. 2023; 120(4):358-371.

PMID: 37010578 DOI: 10.1007/s00347-023-01844-2.

Combined phacoviscocanalostomy versus phacoemulsification alone in patients with coexisting cataract and mild-to-moderate open-angle glaucoma; a randomized-controlled trial.

Zarei R, Azimi A, Fakhraei G, Eslami Y, Naderan M, Nouri-Mahdavi K Eye (Lond). 2022; 37(7):1390-1396.

PMID: 35752716 PMC: 10170155. DOI: 10.1038/s41433-022-02152-w.

Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery.

Verma-Fuehring R, Dakroub M, Han H, Hillenkamp J, Loewen N Sci Rep. 2022; 12(1):10584.

PMID: 35732782 PMC: 9218089. DOI: 10.1038/s41598-022-13990-9.

Gonioscopy-assisted Transluminal Trabeculotomy (GATT) combined phacoemulsification surgery: Outcomes at a 2-year follow-up.

Wan Y, Cao K, Wang J, Sun Y, Du R, Wang Z Eye (Lond). 2022; 37(6):1258-1263.

PMID: 35610359 PMC: 10102214. DOI: 10.1038/s41433-022-02087-2.

References

Grieshaber M, Pienaar A, Olivier J, Stegmann R . Channelography: imaging of the aqueous outflow pathway with flexible microcatheter and fluorescein in canaloplasty. Klin Monbl Augenheilkd. 2009; 226(4):245-8. DOI: 10.1055/s-0028-1109305. View

Fellman R, Feuer W, Grover D . Episcleral Venous Fluid Wave Correlates with Trabectome Outcomes: Intraoperative Evaluation of the Trabecular Outflow Pathway. Ophthalmology. 2015; 122(12):2385-91.e1. DOI: 10.1016/j.ophtha.2015.08.038. View

Huang A, Li M, Yang D, Wang H, Wang N, Weinreb R . Aqueous Angiography in Living Nonhuman Primates Shows Segmental, Pulsatile, and Dynamic Angiographic Aqueous Humor Outflow. Ophthalmology. 2017; 124(6):793-803. PMC: 5484000. DOI: 10.1016/j.ophtha.2017.01.030. View

Hann C, Vercnocke A, Bentley M, Jorgensen S, Fautsch M . Anatomic changes in Schlemm's canal and collector channels in normal and primary open-angle glaucoma eyes using low and high perfusion pressures. Invest Ophthalmol Vis Sci. 2014; 55(9):5834-41. PMC: 4165370. DOI: 10.1167/iovs.14-14128. View

Waxman S, Loewen R, Dang Y, Watkins S, Watson A, Loewen N . High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes. Invest Ophthalmol Vis Sci. 2018; 59(6):2371-2380. PMC: 5939687. DOI: 10.1167/iovs.17-23075. View

Tripathi R . Ultrastructure of Schlemm's canal in relation to aqueous outflow. Exp Eye Res. 1968; 7(3):335-41. DOI: 10.1016/s0014-4835(68)80047-8. View

Loewen R, Brown E, Scott G, Parikh H, Schuman J, Loewen N . Quantification of Focal Outflow Enhancement Using Differential Canalograms. Invest Ophthalmol Vis Sci. 2016; 57(6):2831-8. PMC: 5113980. DOI: 10.1167/iovs.16-19541. View

Karpinich N, Caron K . Schlemm's canal: more than meets the eye, lymphatics in disguise. J Clin Invest. 2014; 124(9):3701-3. PMC: 4151199. DOI: 10.1172/JCI77507. View

Aktas Z, Tian B, McDonald J, Yamamato R, Larsen C, Kiland J . Application of canaloplasty in glaucoma gene therapy: where are we?. J Ocul Pharmacol Ther. 2014; 30(2-3):277-82. PMC: 3991989. DOI: 10.1089/jop.2013.0203. View

10.

Xin C, Johnstone M, Wang N, Wang R . OCT Study of Mechanical Properties Associated with Trabecular Meshwork and Collector Channel Motion in Human Eyes. PLoS One. 2016; 11(9):e0162048. PMC: 5012558. DOI: 10.1371/journal.pone.0162048. View

11.

Ye W, Gong H, Sit A, Johnson M, Freddo T . Interendothelial junctions in normal human Schlemm's canal respond to changes in pressure. Invest Ophthalmol Vis Sci. 1997; 38(12):2460-8. View

12.

Dang Y, Loewen R, Parikh H, Roy P, Loewen N . Gene transfer to the outflow tract. Exp Eye Res. 2016; 158:73-84. PMC: 5083245. DOI: 10.1016/j.exer.2016.04.023. View

13.

Fellman R, Grover D . Episcleral venous fluid wave: intraoperative evidence for patency of the conventional outflow system. J Glaucoma. 2013; 23(6):347-50. DOI: 10.1097/IJG.0b013e31827a06d8. View

14.

Yun H, Wang Y, Zhou Y, Wang K, Sun M, Stolz D . Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model. Commun Biol. 2018; 1:216. PMC: 6283842. DOI: 10.1038/s42003-018-0227-z. View

15.

Xin C, Tian N, Li M, Wang H, Wang N . Mechanism of the reconstruction of aqueous outflow drainage. Sci China Life Sci. 2017; 61(5):534-540. DOI: 10.1007/s11427-017-9140-8. View

16.

Thomson B, Heinen S, Jeansson M, Ghosh A, Fatima A, Sung H . A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest. 2014; 124(10):4320-4. PMC: 4191022. DOI: 10.1172/JCI77162. View

17.

Loewen R, Brown E, Roy P, Schuman J, Sigal I, Loewen N . Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms. PLoS One. 2016; 11(3):e0151754. PMC: 4801333. DOI: 10.1371/journal.pone.0151754. View

18.

McDonnell F, Dismuke W, Overby D, Stamer W . Pharmacological regulation of outflow resistance distal to Schlemm's canal. Am J Physiol Cell Physiol. 2018; 315(1):C44-C51. PMC: 6087729. DOI: 10.1152/ajpcell.00024.2018. View

19.

Yang C, Liu Y, Lu Z, Ren R, Gong H . Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013; 54(8):5859-70. PMC: 3757907. DOI: 10.1167/iovs.12-10930. View

20.

Aref A . Sustained drug delivery for glaucoma: current data and future trends. Curr Opin Ophthalmol. 2016; 28(2):169-174. DOI: 10.1097/ICU.0000000000000334. View