Photothermogenetic Inhibition of Cancer Stemness by Near-infrared-light-activatable Nanocomplexes

Overview

Journal Nat Commun

Specialty Biology

Date 2020 Aug 19

PMID 32807785

Citations 11

Authors

Yue Yu

Xi Yang

Sheethal Reghu

Sunil C Kaul

Renu Wadhwa

Eijiro Miyako

Affiliations

Soon will be listed here.

Abstract

Strategies for eradicating cancer stem cells (CSCs) are urgently required because CSCs are resistant to anticancer drugs and cause treatment failure, relapse and metastasis. Here, we show that photoactive functional nanocarbon complexes exhibit unique characteristics, such as homogeneous particle morphology, high water dispersibility, powerful photothermal conversion, rapid photoresponsivity and excellent photothermal stability. In addition, the present biologically permeable second near-infrared (NIR-II) light-induced nanocomplexes photo-thermally trigger calcium influx into target cells overexpressing the transient receptor potential vanilloid family type 2 (TRPV2). This combination of nanomaterial design and genetic engineering effectively eliminates cancer cells and suppresses stemness of cancer cells in vitro and in vivo. Finally, in molecular analyses of mechanisms, we show that inhibition of cancer stemness involves calcium-mediated dysregulation of the Wnt/β-catenin signalling pathway. The present technological concept may lead to innovative therapies to address the global issue of refractory cancers.

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