The Tripartite Interaction of Host Immunity- Infection-Gut Microbiota

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2020 Aug 19

PMID 32806491

Citations 15

Authors

Shuzhong Li

Surajit De Mandal

Xiaoxia Xu

Fengliang Jin

Affiliations

Soon will be listed here.

Abstract

(Bt) is an important cosmopolitan bacterial entomopathogen, which produces various protein toxins that have been expressed in transgenic crops. The evolved molecular interaction between the insect immune system and gut microbiota is changed during the Bt infection process. The host immune response, such as the expression of induced antimicrobial peptides (AMPs), the melanization response, and the production of reactive oxygen species (ROS), varies with different doses of Bt infection. Moreover, infection changes the abundance and structural composition of the intestinal bacteria community. The activated immune response, together with dysbiosis of the gut microbiota, also has an important effect on Bt pathogenicity and insect resistance to Bt. In this review, we attempt to clarify this tripartite interaction of host immunity, Bt infection, and gut microbiota, especially the important role of key immune regulators and symbiotic bacteria in the Bt killing activity. Increasing the effectiveness of biocontrol agents by interfering with insect resistance and controlling symbiotic bacteria can be important steps for the successful application of microbial biopesticides.

Citing Articles

Carry-over effects of Bacillus thuringiensis on tolerant Aedes albopictus mosquitoes.

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A comprehensive analysis of the defense responses of Odontotermes formosanus (Shiraki) provides insights into the changes during Serratia marcescens infection.

Wang Z, Wang M, Zhou Y, Feng K, Tang F BMC Genomics. 2024; 25(1):1044.

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The influence of inactivated entomopathogenic bacterium on the immune responses of the Colorado potato beetle.

Polenogova O, Kryukova N, Klementeva T, Artemchenko A, Lukin A, Khodyrev V PeerJ. 2024; 12:e18259.

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Microbiome analysis of (Lepidoptera, Noctuidae) larvae exposed to (Bt) endotoxins.

Castaneda-Molina Y, Marulanda-Moreno S, Saldamando-Benjumea C, Junca H, Moreno-Herrera C, Cadavid-Restrepo G PeerJ. 2023; 11:e15916.

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Colonization Resistance of Symbionts in Their Insect Hosts.

Wang Z, Yong H, Zhang S, Liu Z, Zhao Y Insects. 2023; 14(7).

PMID: 37504600 PMC: 10380809. DOI: 10.3390/insects14070594.

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