Epidermal Resident γδ T Cell Development and Function in Skin

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2020 Aug 18

PMID 32803399

Citations 7

Authors

Yingping Xu

Peter Dimitrion

Steven Cvetkovski

Li Zhou

Qing-Sheng Mi

Affiliations

Soon will be listed here.

Abstract

Epidermal resident γδ T cells, or dendritic epidermal T cells (DETCs) in mice, are a unique and conserved population of γδ T cells enriched in the epidermis, where they serve as the regulators of immune responses and sense skin injury. Despite the great advances in the understanding of the development, homeostasis, and function of DETCs in the past decades, the origin and the underlying molecular mechanisms remain elusive. Here, we reviewed the recent research progress on DETCs, including their origin and homeostasis in the skin, especially at transcriptional and epigenetic levels, and discuss the involvement of DETCs in skin diseases.

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