Molecular Aspects of Epithelial γδ T Cell Regulation

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2011 Apr 13

PMID 21481636

Citations 14

Authors

Deborah A Witherden

Wendy L Havran

Affiliations

Soon will be listed here.

Abstract

γδ T cells lie at the interface between innate and adaptive immunity, sharing features with both arms of the immune system. The vast majority of γδ T cells reside in epithelial layers of tissues such as skin, gut, lung, tongue and reproductive tract where they provide a first line of defense against environmental attack. The existence of epithelium-resident γδ T cells has been known for over 20 years but our understanding of the molecular events regulating development and function of these cells is incomplete. We review recent advances in the field, with particular emphasis on the γδ T cell population resident in mouse epidermis. These studies have enhanced our knowledge and understanding of the life cycle of this enigmatic population of cells.

Citing Articles

Unraveling the Role of Epithelial Cells in the Development of Chronic Rhinosinusitis.

Ha J, Cho H Int J Mol Sci. 2023; 24(18).

PMID: 37762530 PMC: 10531804. DOI: 10.3390/ijms241814229.

Skin γδ T Cells and Their Function in Wound Healing.

Hu W, Shang R, Yang J, Chen C, Liu Z, Liang G Front Immunol. 2022; 13:875076.

PMID: 35479079 PMC: 9035842. DOI: 10.3389/fimmu.2022.875076.

Epidermal resident γδ T cell development and function in skin.

Xu Y, Dimitrion P, Cvetkovski S, Zhou L, Mi Q Cell Mol Life Sci. 2020; 78(2):573-580.

PMID: 32803399 PMC: 11073445. DOI: 10.1007/s00018-020-03613-9.

Protective Role of T Cells in Different Pathogen Infections and Its Potential Clinical Application.

Zhao Y, Lin L, Xiao Z, Li M, Wu X, Li W J Immunol Res. 2018; 2018:5081634.

PMID: 30116753 PMC: 6079409. DOI: 10.1155/2018/5081634.

Radiation-Induced Dermatitis is Mediated by IL17-Expressing γδ T Cells.

Liao W, Hei T, Cheng S Radiat Res. 2017; 187(4):454-464.

PMID: 28406748 PMC: 5524538. DOI: 10.1667/RR007CC.1.

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