Advances in Optical Mapping for Genomic Research

Overview

Journal Comput Struct Biotechnol J

Specialty Biotechnology

Date 2020 Aug 18

PMID 32802277

Citations 45

Authors

Yuxuan Yuan

Claire Yik-Lok Chung

Ting-Fung Chan

Affiliations

Soon will be listed here.

Abstract

Recent advances in optical mapping have allowed the construction of improved genome assemblies with greater contiguity. Optical mapping also enables genome comparison and identification of large-scale structural variations. Association of these large-scale genomic features with biological functions is an important goal in plant and animal breeding and in medical research. Optical mapping has also been used in microbiology and still plays an important role in strain typing and epidemiological studies. Here, we review the development of optical mapping in recent decades to illustrate its importance in genomic research. We detail its applications and algorithms to show its specific advantages. Finally, we discuss the challenges required to facilitate the optimization of optical mapping and improve its future development and application.

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