Plasma Vascular Adhesion Protein-1 Levels Correlate Positively with Frailty Severity in Older Adults

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Aug 15

PMID 32791695

Citations 3

Authors

Hsien-Liang Huang

Chin-Hao Chang

Chin-Ying Chen

Jen-Kuei Peng

Yu-Ting Wang

Ching-Yu Chen

Chih-Cheng Hsu

Chung-Sheng Lee

Jaw-Shiun Tsai

Affiliations

Soon will be listed here.

Abstract

Geriatric frailty is associated with increased mortality and links to increased inflammatory activity. Vascular adhesion protein-1 (VAP-1) is important in inflammatory process. This study investigates the relationship between plasma VAP-1 level and frailty in older adults.The cross-sectional study recruited community dwelling older adults from a hospital-based comprehensive geriatric assessment program. The demographic data, Fried Frailty Index, metabolic and inflammatory parameters were assessed.A total of 151 participants (76 women, 50.3%) were included in the analysis, and the age (mean ± standard deviation) was 77.1 ± 6.1 years. The mean plasma VAP-1 level (ng/mL) was significantly different (P = .029) among different frailty groups (346.3 ± 86.5 in the robust older adults, 371.6 ± 107.9 in the pre-frail older adults, and 416.6 ± 141.1 in the frail older adults). Multivariate ordered logistic regression analysis also demonstrated that plasma VAP-1 levels were positively associated with frailty severity (P = .039). Analysis of the frailty components with plasma VAP-1 levels showed that the elderly who had "exhaustion" (P = .016) or "weakness" (P = .025) tended to have higher plasma VAP-1 levels.The data support that VAP-1 might represent a potential plasma biomarker of frailty.

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