Biomarkers for Physical Frailty and Sarcopenia: State of the Science and Future Developments

Overview

Journal J Cachexia Sarcopenia Muscle

Date 2015 Dec 18

PMID 26675566

Citations 109

Authors

Riccardo Calvani

Federico Marini

Matteo Cesari

Matteo Tosato

Stefan D Anker

Stephan von Haehling

Ram R Miller

Roberto Bernabei

Francesco Landi

Emanuele Marzetti

Affiliations

Soon will be listed here.

Abstract

Physical frailty and sarcopenia are two common and largely overlapping geriatric conditions upstream of the disabling cascade. The lack of a unique operational definition for physical frailty and sarcopenia and the complex underlying pathophysiology make the development of biomarkers for these conditions extremely challenging. Indeed, the current definitional ambiguities of physical frailty and sarcopenia, together with their heterogeneous clinical manifestations, impact the accuracy, specificity, and sensitivity of individual biomarkers proposed so far. In this review, the current state of the art in the development of biomarkers for physical frailty and sarcopenia is presented. A novel approach for biomarker identification and validation is also introduced that moves from the 'one fits all' paradigm to a multivariate methodology.

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References

Rantanen T, Guralnik J, Foley D, Masaki K, Leveille S, Curb J . Midlife hand grip strength as a predictor of old age disability. JAMA. 1999; 281(6):558-60. DOI: 10.1001/jama.281.6.558. View

Asea A, Kraeft S, Stevenson M, Chen L, Finberg R, Koo G . HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med. 2000; 6(4):435-42. DOI: 10.1038/74697. View

. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69(3):89-95. DOI: 10.1067/mcp.2001.113989. View

Fried L, Tangen C, Walston J, Newman A, Hirsch C, Gottdiener J . Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56(3):M146-56. DOI: 10.1093/gerona/56.3.m146. View

Visser M, Pahor M, Taaffe D, Goodpaster B, Simonsick E, Newman A . Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2002; 57(5):M326-32. DOI: 10.1093/gerona/57.5.m326. View

Studenski S, Perera S, Wallace D, Chandler J, Duncan P, Rooney E . Physical performance measures in the clinical setting. J Am Geriatr Soc. 2003; 51(3):314-22. DOI: 10.1046/j.1532-5415.2003.51104.x. View

Semba R, Blaum C, Guralnik J, Moncrief D, Ricks M, Fried L . Carotenoid and vitamin E status are associated with indicators of sarcopenia among older women living in the community. Aging Clin Exp Res. 2004; 15(6):482-7. DOI: 10.1007/BF03327377. View

Cesari M, Penninx B, Pahor M, Lauretani F, Corsi A, Williams G . Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2004; 59(3):242-8. DOI: 10.1093/gerona/59.3.m242. View

Penninx B, Pahor M, Cesari M, Corsi A, Woodman R, Bandinelli S . Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc. 2004; 52(5):719-24. DOI: 10.1111/j.1532-5415.2004.52208.x. View

10.

Jansen J, Hoefsloot H, Boelens H, van der Greef J, Smilde A . Analysis of longitudinal metabolomics data. Bioinformatics. 2004; 20(15):2438-46. DOI: 10.1093/bioinformatics/bth268. View

11.

Penninx B, Kritchevsky S, Newman A, Nicklas B, Simonsick E, Rubin S . Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc. 2004; 52(7):1105-13. DOI: 10.1111/j.1532-5415.2004.52308.x. View

12.

Sayer A, Syddall H, Gilbody H, Dennison E, Cooper C . Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study. J Gerontol A Biol Sci Med Sci. 2004; 59(9):M930-4. DOI: 10.1093/gerona/59.9.m930. View

13.

Smilde A, Jansen J, Hoefsloot H, Lamers R, van der Greef J, Timmerman M . ANOVA-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data. Bioinformatics. 2005; 21(13):3043-8. DOI: 10.1093/bioinformatics/bti476. View

14.

Visser M, Kritchevsky S, Newman A, Goodpaster B, Tylavsky F, Nevitt M . Lower serum albumin concentration and change in muscle mass: the Health, Aging and Body Composition Study. Am J Clin Nutr. 2005; 82(3):531-7. DOI: 10.1093/ajcn.82.3.531. View

15.

Cesari M, Kritchevsky S, Nicklas B, Penninx B, Holvoet P, Koh-Banerjee P . Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition Study. Arch Intern Med. 2005; 165(18):2148-54. DOI: 10.1001/archinte.165.18.2148. View

16.

Robinson M, Tidwell J, Gould T, Taylor A, Newbern J, Graves J . Extracellular heat shock protein 70: a critical component for motoneuron survival. J Neurosci. 2005; 25(42):9735-45. PMC: 6725726. DOI: 10.1523/JNEUROSCI.1912-05.2005. View

17.

Onder G, Liperoti R, Russo A, Soldato M, Capoluongo E, Volpato S . Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study. Am J Physiol Endocrinol Metab. 2006; 291(4):E829-34. DOI: 10.1152/ajpendo.00138.2006. View

18.

Kuh D, Hardy R, Butterworth S, Okell L, Richards M, Wadsworth M . Developmental origins of midlife physical performance: evidence from a British birth cohort. Am J Epidemiol. 2006; 164(2):110-21. DOI: 10.1093/aje/kwj193. View

19.

Kuh D, Hardy R, Butterworth S, Okell L, Wadsworth M, Cooper C . Developmental origins of midlife grip strength: findings from a birth cohort study. J Gerontol A Biol Sci Med Sci. 2006; 61(7):702-6. DOI: 10.1093/gerona/61.7.702. View

20.

Morrow D, de Lemos J . Benchmarks for the assessment of novel cardiovascular biomarkers. Circulation. 2007; 115(8):949-52. DOI: 10.1161/CIRCULATIONAHA.106.683110. View