Brains, Bacteria and Behaviors: the Role of Interferon-gamma in the Pathogenesis of Pneumococcal Meningitis

Overview

Journal Neural Regen Res

Date 2020 Aug 14

PMID 32788465

Citations 2

Authors

Lay Khoon Too

Andrew Mitchell

Affiliations

Soon will be listed here.

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The Role of Inflammation and Infection in Age-Related Neurodegenerative Diseases: Lessons From Bacterial Meningitis Applied to Alzheimer Disease and Age-Related Macular Degeneration.

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References

Too L, Yau B, Baxter A, McGregor I, Hunt N . Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis. Sci Rep. 2019; 9(1):16189. PMC: 6838097. DOI: 10.1038/s41598-019-52212-7. View

Sheng W, Zong Y, Mohammad A, Ajit D, Cui J, Han D . Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia. J Neuroinflammation. 2011; 8:121. PMC: 3206447. DOI: 10.1186/1742-2094-8-121. View

Klein M, Obermaier B, Angele B, Pfister H, Wagner H, Koedel U . Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. J Infect Dis. 2008; 198(7):1028-36. DOI: 10.1086/591626. View

Too L, Ball H, McGregor I, Hunt N . The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis. Brain Behav Immun. 2014; 40:252-68. DOI: 10.1016/j.bbi.2014.02.020. View

Bewersdorf J, Grandgirard D, Koedel U, Leib S . Novel and preclinical treatment strategies in pneumococcal meningitis. Curr Opin Infect Dis. 2017; 31(1):85-92. DOI: 10.1097/QCO.0000000000000416. View

Dantzer R . Cytokine, sickness behavior, and depression. Immunol Allergy Clin North Am. 2009; 29(2):247-64. PMC: 2740752. DOI: 10.1016/j.iac.2009.02.002. View

Mitchell A, Yau B, McQuillan J, Ball H, Too L, Abtin A . Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis. J Immunol. 2012; 189(10):4970-80. DOI: 10.4049/jimmunol.1201687. View

Koelman D, Brouwer M, van de Beek D . Resurgence of pneumococcal meningitis in Europe and Northern America. Clin Microbiol Infect. 2019; 26(2):199-204. DOI: 10.1016/j.cmi.2019.04.032. View

Zheng C, Zhou X, Wang J . The dual roles of cytokines in Alzheimer's disease: update on interleukins, TNF-α, TGF-β and IFN-γ. Transl Neurodegener. 2016; 5:7. PMC: 4822284. DOI: 10.1186/s40035-016-0054-4. View

10.

Voikar V, Colacicco G, Gruber O, Vannoni E, Lipp H, Wolfer D . Conditioned response suppression in the IntelliCage: assessment of mouse strain differences and effects of hippocampal and striatal lesions on acquisition and retention of memory. Behav Brain Res. 2010; 213(2):304-12. DOI: 10.1016/j.bbr.2010.05.019. View

11.

Too L, McQuillan J, Ball H, Kanai M, Nakamura T, Funakoshi H . The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behav Brain Res. 2014; 270:179-95. DOI: 10.1016/j.bbr.2014.05.018. View