The Dual Roles of Cytokines in Alzheimer's Disease: Update on Interleukins, TNF-α, TGF-β and IFN-γ

Overview

Journal Transl Neurodegener

Publisher Biomed Central

Date 2016 Apr 8

PMID 27054030

Citations 137

Authors

Cong Zheng

Xin-Wen Zhou

Jian-Zhi Wang

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in the elderly. Although the mechanisms underlying AD neurodegeneration are not fully understood, it is well recognized that inflammation plays a crucial role in the initiation and/or deterioration of AD neurodegeneration. Increasing evidence suggests that different cytokines, including interleukins, TNF-α, TGF-β and IFN-γ, are actively participated in AD pathogenesis and may serve as diagnostic or therapeutic targets for AD neurodegeneration. Here, we review the progress in understanding the important role that these cytokines or neuroinflammation has played in AD etiology and pathogenesis.

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