The Clinical Application of Mesenchymal Stem Cells in Liver Disease: the Current Situation and Potential Future

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2020 Aug 11

PMID 32775366

Citations 26

Authors

Sainan Zhang

Ya Yang

Linxiao Fan

Fen Zhang

Lanjuan Li

Affiliations

Soon will be listed here.

Abstract

Liver disease is a major health issue which present poor clinical treatment performance. Cirrhosis and liver failure are common clinical manifestations of liver diseases. Liver transplantation is recognized as the ultimate and most efficient therapy to the end stage of liver disease. But it was limited by the shortage of honor organs and high cost. Nowadays, stem cell therapy gained more and more attention due to its attractive efficacy in treating liver disease especially in cirrhosis during the clinical trials. Mesenchymal stem cell (MSC) can be differentiated into hepatocytes, promote liver regeneration, inhibit liver fibrosis and induce liver apoptosis, particularly via paracrine mechanisms. This review will highlight recent clinical applications of MSC, providing the available evidence and discussing some unsolved questions in treating liver disease.

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Human Liver MSCs Retain Their Basic Cellular Properties in Chronically Inflamed Liver Tissue.

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