Molecular and Immunological Diagnostic Tests of COVID-19: Current Status and Challenges

Overview

Journal iScience

Publisher Cell Press

Date 2020 Aug 11

PMID 32771976

Citations 87

Authors

Tugba Kilic

Ralph Weissleder

Hakho Lee

Affiliations

Soon will be listed here.

Abstract

Rapid spread of coronavirus disease 2019 (COVID-19) is ravaging the globe. Since its first report in December 2019, COVID-19 cases have exploded to over 14 million as of July 2020, claiming more than 600,000 lives. Implementing fast and widespread diagnostic tests is paramount to contain COVID-19, given the current lack of an effective therapeutic or vaccine. This review focuses on a broad description of currently available diagnostic tests to detect either the virus (SARS-CoV-2) or virus-induced immune responses. We specifically explain the working mechanisms of these tests and compare their analytical performance. These analyses will assist in selecting most effective tests for a given application, for example, epidemiology or global pandemic research, population screening, hospital-based testing, home-based and point-of-care testing, and therapeutic trials. Finally, we lay out the shortcomings of certain tests and future needs.

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