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An Insight on Medicinal Attributes of 1,2,4-triazoles

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Journal Eur J Med Chem
Specialty Chemistry
Date 2020 Aug 11
PMID 32771798
Citations 47
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Abstract

The present review aims to summarize the pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant, antituberculosis, antiviral, antiparasitic, analgesic and anti-inflammatory agents, etc. along with structure-activity relationship. The comprehensive compilation of work carried out in the last decade on 1,2,4-triazole nucleus will provide inevitable scope for researchers for the advancement of novel potential drug candidates having better efficacy and selectivity.

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References
1.
Mustafa M, Abdelhamid D, Abdelhafez E, Ibrahim M, Gamal-Eldeen A, Aly O . Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues. Eur J Med Chem. 2017; 141:293-305. DOI: 10.1016/j.ejmech.2017.09.063. View

2.
Mohamed N, Sheha M, Hassan H, Abdel-Hafez L, Omar F . Synthesis, antimicrobial activity and molecular modeling study of 3-(5-amino-(2H)-1,2,4-triazol-3-yl]-naphthyridinones as potential DNA-gyrase inhibitors. Bioorg Chem. 2018; 81:599-611. DOI: 10.1016/j.bioorg.2018.08.031. View

3.
Lamie P, Ali W, Bazgier V, Rarova L . Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study. Eur J Med Chem. 2016; 123:803-813. DOI: 10.1016/j.ejmech.2016.08.013. View

4.
Pokuri S, Singla R, Bhat V, Shenoy G . Insights on the antioxidant potential of 1, 2, 4-triazoles: synthesis, screening & QSAR studies. Curr Drug Metab. 2014; 15(4):389-97. DOI: 10.2174/1389200215666140908101958. View

5.
Kandeel M, Refaat H, Kassab A, Shahin I, Abdelghany T . Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno[2,3-d]pyrimidine and thieno[3,2-e] triazolo[4,3-c]pyrimidine derivatives. Eur J Med Chem. 2014; 90:620-32. DOI: 10.1016/j.ejmech.2014.12.009. View