Infertility Duration and Pre-operative Sperm Progressive Motility Are Significant Factors of Spontaneous Pregnancy After Varicocele Repair

Problem: Varicocele may lead to testicular dysfunction and male infertility. Varicocelectomy can improve both semen quality and post-operative spontaneous pregnancy. However, different patients benefit distinctly from the surgery. Therefore, the study aims at examining the possible factors of spontaneous pregnancy after laparoscopic varicocelectomy in infertile men.

Method Of Study: Clinical data of 196 infertile men who underwent laparoscopic varicocelectomy at our institute were collected from December 2013 to February 2019. Follow-up data were available for 148 patients. All the patients were treated with laparoscopic varicocelectomy performed by experienced urological doctors. Possible pre-operative factors of spontaneous pregnancy after laparoscopic varicocelectomy were retrospectively analyzed.

Results: After a mean follow-up of 29.1 ± 12.6 months (range 12-74 months), 74 (50%) of couples achieved spontaneous pregnancy. Univariate analysis revealed that short infertility duration, secondary infertility, and high sperm progressive motility were significant predictors of spontaneous pregnancy after laparoscopic varicocelectomy. Multivariate analysis revealed that short infertility duration (≤2 years) and high sperm progressive motility (>30%) were independent predictors.

Conclusion: Both infertility duration and pre-operative sperm progressive motility could serve as independent factors of spontaneous pregnancy after laparoscopic varicocelectomy.