The Proteasome Controls ESCRT-III-mediated Cell Division in an Archaeon

Overview

Journal Science

Specialty Science

Date 2020 Aug 9

PMID 32764038

Citations 34

Authors

Gabriel Tarrason Risa

Fredrik Hurtig

Sian Bray

Anne E Hafner

Lena Harker-Kirschneck

Peter Faull

Colin Davis

Dimitra Papatziamou

Delyan R Mutavchiev

Catherine Fan

Leticia Meneguello

Andre Arashiro Pulschen

Gautam Dey

Sian Culley

Mairi Kilkenny

Diorge P Souza

Luca Pellegrini

Robertus A M de Bruin

Ricardo Henriques

Ambrosius P Snijders

Andela Saric

Ann-Christin Lindas

Nicholas P Robinson

Buzz Baum

Affiliations

Soon will be listed here.

Abstract

is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in , we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III-mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control.

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