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Age-specific SARS-CoV-2 Infection Fatality Ratio and Associated Risk Factors, Italy, February to April 2020

Overview
Journal Euro Surveill
Specialty Infectious Diseases
Date 2020 Aug 9
PMID 32762797
Citations 40
Authors
Piero Poletti
Marcello Tirani
Danilo Cereda
Filippo Trentini
Giorgio Guzzetta
Valentina Marziano
Sabrina Buoro
Simona Riboli
Lucia Crottogini
Raffaella Piccarreta
Alessandra Piatti
Giacomo Grasselli
Alessia Melegaro
Maria Gramegna
Marco Ajelli
Stefano Merler
Affiliations
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Abstract

We analysed 5,484 close contacts of coronavirus disease (COVID-19) cases in Italy, all tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection fatality ratio was 0.43% (95% confidence interval (CI): 0.21-0.79) for individuals younger than 70 years and 10.5% (95% CI: 8.0-13.6) for older individuals. Risk of death after infection was 62% lower (95% CI: 31-80) in clusters identified after 16 March 2020 and 1.8-fold higher for males (95% CI: 1.03-3.16).

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References
1.
Buitrago-Garcia D, Egli-Gany D, Counotte M, Hossmann S, Imeri H, Ipekci A . Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis. PLoS Med. 2020; 17(9):e1003346. PMC: 7508369. DOI: 10.1371/journal.pmed.1003346. View
2.
Verity R, Okell L, Dorigatti I, Winskill P, Whittaker C, Imai N . Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020; 20(6):669-677. PMC: 7158570. DOI: 10.1016/S1473-3099(20)30243-7. View
3.
Perez-Saez J, Lauer S, Kaiser L, Regard S, Delaporte E, Guessous I . Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland. Lancet Infect Dis. 2020; 21(4):e69-e70. PMC: 7833057. DOI: 10.1016/S1473-3099(20)30584-3. View
4.
Russell T, Hellewell J, Jarvis C, van Zandvoort K, Abbott S, Ratnayake R . Estimating the infection and case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess cruise ship, February 2020. Euro Surveill. 2020; 25(12). PMC: 7118348. DOI: 10.2807/1560-7917.ES.2020.25.12.2000256. View
5.
Meyerowitz-Katz G, Merone L . A systematic review and meta-analysis of published research data on COVID-19 infection fatality rates. Int J Infect Dis. 2020; 101:138-148. PMC: 7524446. DOI: 10.1016/j.ijid.2020.09.1464. View