Alternative Splicing and Cancer: Insights, Opportunities, and Challenges from an Expanding View of the Transcriptome

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2020 Aug 5

PMID 32747477

Citations 49

Authors

Sara Cherry

Kristen W Lynch

Affiliations

Soon will be listed here.

Abstract

Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years regarding the causes and functional relevance of alternative splicing in cancer. Here we discuss the current understanding of the connections between splicing and cancer, with a focus on the most recent findings. We also discuss remaining questions and challenges that must be addressed in order to use our knowledge of splicing to guide the diagnosis and treatment of cancer.

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