Circulating Serum Exosomal MiR-20b-5p and MiR-3187-5p As Efficient Diagnostic Biomarkers for Early-stage Non-small Cell Lung Cancer

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2020 Aug 4

PMID 32741216

Citations 18

Authors

Zhi-Jun Zhang

Xing-Guo Song

Li Xie

Kang-Yu Wang

You-Yong Tang

Miao- Yu

Xiao-Dong Feng

Xian-Rang Song

Affiliations

Soon will be listed here.

Abstract

The high mortality of non-small cell lung cancer (NSCLC) is mainly because the cancer has progressed to a more advanced stage before diagnosis. If NSCLC can be diagnosed at early stages, especially stage 0 or I, the overall survival rate will be largely improved by definitive treatment such as lobectomy. We herein validated two novel circulating serum ExmiRs as diagnostic biomarkers for early-stage NSCLC to fulfill the unmet medical need. Considering the number of specimens in this study, circulating serum exosomal miR-20b-5p and miR-3187-5p are putative NSCLC biomarkers, which need to be further investigated in a larger randomized controlled clinical trial.

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References

Liu X, Pan B, Sun L, Chen X, Zeng K, Hu X . Circulating Exosomal miR-27a and miR-130a Act as Novel Diagnostic and Prognostic Biomarkers of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2018; 27(7):746-754. DOI: 10.1158/1055-9965.EPI-18-0067. View

Najminejad H, Kalantar S, Abdollahpour-Alitappeh M, Karimi M, Seifalian A, Gholipourmalekabadi M . Emerging roles of exosomal miRNAs in breast cancer drug resistance. IUBMB Life. 2019; 71(11):1672-1684. DOI: 10.1002/iub.2116. View

Fortunato O, Gasparini P, Boeri M, Sozzi G . Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer. Cancers (Basel). 2019; 11(6). PMC: 6627875. DOI: 10.3390/cancers11060888. View

Bhagirath D, Yang T, Bucay N, Sekhon K, Majid S, Shahryari V . microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer. Cancer Res. 2018; 78(7):1833-1844. PMC: 5890910. DOI: 10.1158/0008-5472.CAN-17-2069. View

Kawai S, Fujii T, Kukimoto I, Yamada H, Yamamoto N, Kuroda M . Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia. Sci Rep. 2018; 8(1):7070. PMC: 5935744. DOI: 10.1038/s41598-018-25310-1. View

Alipoor S, Mortaz E, Varahram M, Movassaghi M, Kraneveld A, Garssen J . The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer. Front Immunol. 2018; 9:819. PMC: 5915468. DOI: 10.3389/fimmu.2018.00819. View

Vignard V, Labbe M, Marec N, Andre-Gregoire G, Jouand N, Fonteneau J . MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma. Cancer Immunol Res. 2019; 8(2):255-267. DOI: 10.1158/2326-6066.CIR-19-0522. View

Lai J, Du B, Wang Y, Wu R, Yu Z . Next-generation sequencing of circulating tumor DNA for detection of gene mutations in lung cancer: implications for precision treatment. Onco Targets Ther. 2018; 11:9111-9116. PMC: 6299472. DOI: 10.2147/OTT.S174877. View

Nakamura S, Sadakari Y, Ohtsuka T, Okayama T, Nakashima Y, Gotoh Y . Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol. 2019; 26(7):2104-2111. DOI: 10.1245/s10434-019-07269-z. View

10.

Singal G, Miller P, Agarwala V, Li G, Kaushik G, Backenroth D . Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non-Small Cell Lung Cancer Using a Clinicogenomic Database. JAMA. 2019; 321(14):1391-1399. PMC: 6459115. DOI: 10.1001/jama.2019.3241. View

11.

Kurahashi R, Kadomatsu T, Baba M, Hara C, Itoh H, Miyata K . MicroRNA-204-5p: A novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma. Cancer Sci. 2019; 110(6):1897-1908. PMC: 6549932. DOI: 10.1111/cas.14026. View

12.

Perez-Hernandez J, Olivares D, Forner M, Ortega A, Solaz E, Martinez F . Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension. J Transl Med. 2018; 16(1):228. PMC: 6092786. DOI: 10.1186/s12967-018-1604-6. View

13.

Gallo A, Tandon M, Alevizos I, Illei G . The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS One. 2012; 7(3):e30679. PMC: 3302865. DOI: 10.1371/journal.pone.0030679. View

14.

Sun Y, Mei H, Xu C, Tang H, Wei W . Circulating microRNA-339-5p and -21 in plasma as an early detection predictors of lung adenocarcinoma. Pathol Res Pract. 2017; 214(1):119-125. DOI: 10.1016/j.prp.2017.10.011. View

15.

Ghoreishy A, Khosravi A, Ghaemmaghami A . Exosomal microRNA and stroke: A review. J Cell Biochem. 2019; 120(10):16352-16361. DOI: 10.1002/jcb.29130. View

16.

Okamura K, Takayama K, Izumi M, Harada T, Furuyama K, Nakanishi Y . Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer. Lung Cancer. 2013; 80(1):45-9. DOI: 10.1016/j.lungcan.2013.01.002. View

17.

Ma J, Xu M, Yin M, Hong J, Chen H, Gao Y . Exosomal hsa-miR199a-3p Promotes Proliferation and Migration in Neuroblastoma. Front Oncol. 2019; 9:459. PMC: 6582313. DOI: 10.3389/fonc.2019.00459. View

18.

Zhang W, Ni M, Su Y, Wang H, Zhu S, Zhao A . MicroRNAs in Serum Exosomes as Potential Biomarkers in Clear-cell Renal Cell Carcinoma. Eur Urol Focus. 2017; 4(3):412-419. DOI: 10.1016/j.euf.2016.09.007. View

19.

Oellerich M, Christenson R, Beck J, Walson P . Plasma EGFR mutation testing in non-small cell lung cancer: A value proposition. Clin Chim Acta. 2019; 495:481-486. DOI: 10.1016/j.cca.2019.05.019. View

20.

Huang Z, Zhang L, Zhu D, Shan X, Zhou X, Qi L . A novel serum microRNA signature to screen esophageal squamous cell carcinoma. Cancer Med. 2016; 6(1):109-119. PMC: 5269712. DOI: 10.1002/cam4.973. View