» Articles » PMID: 35317517

Emerging Function and Clinical Significance of Extracellular Vesicle Noncoding RNAs in Lung Cancer

Overview
Publisher Cell Press
Date 2022 Mar 23
PMID 35317517
Authors
Affiliations
Soon will be listed here.
Abstract

Lung cancer (LC) is a commonly diagnosed cancer with an unsatisfactory prognosis. Extracellular vesicles (EVs) are lipid bilayer-delimited particles that mediate cell-cell communication by transporting various biomacromolecules, such as nucleic acids, proteins, and lipids. Noncoding RNAs (ncRNAs), including microRNAs, circular RNAs, and long noncoding RNAs, are important noncoding transcripts that play critical roles in a variety of physiological and pathological processes, especially in cancer. ncRNAs have been verified to be packaged into EVs and transported between LC cells and stromal cells, regulating multiple LC malignant phenotypes, such as proliferation, migration, invasion, epithelial-mesenchymal transition, metastasis, and treatment resistance. Additionally, EVs can be detected in various body fluids and are associated with the stage, grade, and metastasis of LC. Herein, we summarize the biological characteristics and functions of EV ncRNAs in the biological processes of LC, focusing on their potential to serve as diagnostic and prognostic biomarkers of LC as well as their probable role in the clinical treatment of LC. EV ncRNAs provide a new perspective for understanding the mechanism underlying LC pathogenesis and development, which might benefit numerous LC patients in the future.

Citing Articles

Exosomes as mediators of tumor immune escape and immunotherapy in hepatocellular carcinoma.

Guan M, Wang M, Wang W, Li C, Yao L, Zhu H Liver Res. 2025; 6(3):132-138.

PMID: 39958202 PMC: 11791807. DOI: 10.1016/j.livres.2022.08.001.


Ubiquitin-Specific Protease 22 Plays a Key Role in Increasing Extracellular Vesicle Secretion and Regulating Cell Motility of Lung Adenocarcinoma.

Zhen F, Sun Y, Wang H, Liu W, Liang X, Wang Y Adv Sci (Weinh). 2024; 11(38):e2405731.

PMID: 39101247 PMC: 11481270. DOI: 10.1002/advs.202405731.


Mesenchymal Stem Cell-Derived Extracellular Vesicles in Cancer Therapy Resistance: from Biology to Clinical Opportunity.

Shan C, Liang Y, Wang K, Li P Int J Biol Sci. 2024; 20(1):347-366.

PMID: 38164177 PMC: 10750277. DOI: 10.7150/ijbs.88500.


Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility.

Gonzalez-Ruiz J, Baccarelli A, Cantu-de-Leon D, Prada D Curr Environ Health Rep. 2023; 10(4):478-489.

PMID: 38052753 PMC: 10822800. DOI: 10.1007/s40572-023-00421-8.


Non-Coding RNAs in Airway Diseases: A Brief Overview of Recent Data.

Albano G, Gagliardo R, Montalbano A, Profita M Cancers (Basel). 2023; 15(1).

PMID: 36612051 PMC: 9817765. DOI: 10.3390/cancers15010054.


References
1.
Yuwen D, Sheng B, Liu J, Wenyu W, Shu Y . MiR-146a-5p level in serum exosomes predicts therapeutic effect of cisplatin in non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 2017; 21(11):2650-2658. View

2.
Castellano J, Marrades R, Molins L, Vinolas N, Moises J, Canals J . Extracellular Vesicle lincRNA-p21 Expression in Tumor-Draining Pulmonary Vein Defines Prognosis in NSCLC and Modulates Endothelial Cell Behavior. Cancers (Basel). 2020; 12(3). PMC: 7140053. DOI: 10.3390/cancers12030734. View

3.
Zhou Y, Chen F, Xie X, Nie H, Lian S, Zhong C . Tumor-derived Exosome Promotes Metastasis via Altering its Phenotype and Inclusions. J Cancer. 2021; 12(14):4240-4246. PMC: 8176431. DOI: 10.7150/jca.48043. View

4.
Yeung M, Bennasser Y, Watashi K, Le S, Houzet L, Jeang K . Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid. Nucleic Acids Res. 2009; 37(19):6575-86. PMC: 2770672. DOI: 10.1093/nar/gkp707. View

5.
Lemjabbar-Alaoui H, Hassan O, Yang Y, Buchanan P . Lung cancer: Biology and treatment options. Biochim Biophys Acta. 2015; 1856(2):189-210. PMC: 4663145. DOI: 10.1016/j.bbcan.2015.08.002. View