Emerging Function and Clinical Significance of Extracellular Vesicle Noncoding RNAs in Lung Cancer

Overview

Journal Mol Ther Oncolytics

Publisher Cell Press

Date 2022 Mar 23

PMID 35317517

Authors

Chan Shan

Yan Liang

Hongjing Cai

Fei Wang

Xinzhe Chen

Qikun Yin

Kun Wang

Yin Wang

Affiliations

Soon will be listed here.

Abstract

Lung cancer (LC) is a commonly diagnosed cancer with an unsatisfactory prognosis. Extracellular vesicles (EVs) are lipid bilayer-delimited particles that mediate cell-cell communication by transporting various biomacromolecules, such as nucleic acids, proteins, and lipids. Noncoding RNAs (ncRNAs), including microRNAs, circular RNAs, and long noncoding RNAs, are important noncoding transcripts that play critical roles in a variety of physiological and pathological processes, especially in cancer. ncRNAs have been verified to be packaged into EVs and transported between LC cells and stromal cells, regulating multiple LC malignant phenotypes, such as proliferation, migration, invasion, epithelial-mesenchymal transition, metastasis, and treatment resistance. Additionally, EVs can be detected in various body fluids and are associated with the stage, grade, and metastasis of LC. Herein, we summarize the biological characteristics and functions of EV ncRNAs in the biological processes of LC, focusing on their potential to serve as diagnostic and prognostic biomarkers of LC as well as their probable role in the clinical treatment of LC. EV ncRNAs provide a new perspective for understanding the mechanism underlying LC pathogenesis and development, which might benefit numerous LC patients in the future.

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References

Yuwen D, Sheng B, Liu J, Wenyu W, Shu Y . MiR-146a-5p level in serum exosomes predicts therapeutic effect of cisplatin in non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 2017; 21(11):2650-2658. View

Castellano J, Marrades R, Molins L, Vinolas N, Moises J, Canals J . Extracellular Vesicle lincRNA-p21 Expression in Tumor-Draining Pulmonary Vein Defines Prognosis in NSCLC and Modulates Endothelial Cell Behavior. Cancers (Basel). 2020; 12(3). PMC: 7140053. DOI: 10.3390/cancers12030734. View

Zhou Y, Chen F, Xie X, Nie H, Lian S, Zhong C . Tumor-derived Exosome Promotes Metastasis via Altering its Phenotype and Inclusions. J Cancer. 2021; 12(14):4240-4246. PMC: 8176431. DOI: 10.7150/jca.48043. View

Yeung M, Bennasser Y, Watashi K, Le S, Houzet L, Jeang K . Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid. Nucleic Acids Res. 2009; 37(19):6575-86. PMC: 2770672. DOI: 10.1093/nar/gkp707. View

Lemjabbar-Alaoui H, Hassan O, Yang Y, Buchanan P . Lung cancer: Biology and treatment options. Biochim Biophys Acta. 2015; 1856(2):189-210. PMC: 4663145. DOI: 10.1016/j.bbcan.2015.08.002. View

Gu J, Qian H, Shen L, Zhang X, Zhu W, Huang L . Gastric cancer exosomes trigger differentiation of umbilical cord derived mesenchymal stem cells to carcinoma-associated fibroblasts through TGF-β/Smad pathway. PLoS One. 2013; 7(12):e52465. PMC: 3527492. DOI: 10.1371/journal.pone.0052465. View

Santangelo L, Giurato G, Cicchini C, Montaldo C, Mancone C, Tarallo R . The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Cell Rep. 2016; 17(3):799-808. DOI: 10.1016/j.celrep.2016.09.031. View

Zhang W, Ou X, Wu X . Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis. Int J Oncol. 2019; 54(5):1719-1733. PMC: 6438431. DOI: 10.3892/ijo.2019.4742. View

Tao Y, Tang Y, Yang Z, Wu F, Wang L, Yang L . Exploration of Serum Exosomal LncRNA TBILA and AGAP2-AS1 as Promising Biomarkers for Diagnosis of Non-Small Cell Lung Cancer. Int J Biol Sci. 2020; 16(3):471-482. PMC: 6990900. DOI: 10.7150/ijbs.39123. View

10.

Ni J, Zhang X, Li J, Zheng Z, Zhang J, Zhao W . Tumour-derived exosomal lncRNA-SOX2OT promotes bone metastasis of non-small cell lung cancer by targeting the miRNA-194-5p/RAC1 signalling axis in osteoclasts. Cell Death Dis. 2021; 12(7):662. PMC: 8253828. DOI: 10.1038/s41419-021-03928-w. View

11.

Chen X, Wang Z, Tong F, Dong X, Wu G, Zhang R . lncRNA UCA1 Promotes Gefitinib Resistance as a ceRNA to Target FOSL2 by Sponging miR-143 in Non-small Cell Lung Cancer. Mol Ther Nucleic Acids. 2020; 19:643-653. PMC: 6965519. DOI: 10.1016/j.omtn.2019.10.047. View

12.

Han F, Huang D, Huang X, Wang W, Yang S, Chen S . Exosomal microRNA-26b-5p down-regulates ATF2 to enhance radiosensitivity of lung adenocarcinoma cells. J Cell Mol Med. 2020; 24(14):7730-7742. PMC: 7348161. DOI: 10.1111/jcmm.15402. View

13.

Guglas K, Kolodziejczak I, Kolenda T, Kopczynska M, Teresiak A, Sobocinska J . YRNAs and YRNA-Derived Fragments as New Players in Cancer Research and Their Potential Role in Diagnostics. Int J Mol Sci. 2020; 21(16). PMC: 7460810. DOI: 10.3390/ijms21165682. View

14.

Xie Y, Dang W, Zhang S, Yue W, Yang L, Zhai X . The role of exosomal noncoding RNAs in cancer. Mol Cancer. 2019; 18(1):37. PMC: 6408816. DOI: 10.1186/s12943-019-0984-4. View

15.

Domvri K, Petanidis S, Anestakis D, Porpodis K, Bai C, Zarogoulidis P . Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation. Oncotarget. 2020; 11(29):2847-2862. PMC: 7381096. DOI: 10.18632/oncotarget.27675. View

16.

Nie H, Xie X, Zhang D, Zhou Y, Li B, Li F . Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer. Nanoscale. 2019; 12(2):877-887. DOI: 10.1039/c9nr09011h. View

17.

Lawson J, Dickman C, Towle R, Jabalee J, Javer A, Garnis C . Extracellular vesicle secretion of miR-142-3p from lung adenocarcinoma cells induces tumor promoting changes in the stroma through cell-cell communication. Mol Carcinog. 2018; 58(3):376-387. DOI: 10.1002/mc.22935. View

18.

Hu H, Xu H, Lu F, Zhang J, Xu L, Xu S . Exosome-Derived miR-486-5p Regulates Cell Cycle, Proliferation and Metastasis in Lung Adenocarcinoma via Targeting NEK2. Front Bioeng Biotechnol. 2020; 8:259. PMC: 7156548. DOI: 10.3389/fbioe.2020.00259. View

19.

Wei F, Ma C, Zhou T, Dong X, Luo Q, Geng L . Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p. Mol Cancer. 2017; 16(1):132. PMC: 5526308. DOI: 10.1186/s12943-017-0694-8. View

20.

Teng Y, Kang H, Chu Y . Identification of an Exosomal Long Noncoding RNA SOX2-OT in Plasma as a Promising Biomarker for Lung Squamous Cell Carcinoma. Genet Test Mol Biomarkers. 2019; 23(4):235-240. DOI: 10.1089/gtmb.2018.0103. View