Efficacy and Mechanisms of Flavonoids Against the Emerging Opportunistic Nontuberculous Mycobacteria

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Jul 31

PMID 32726972

Citations 7

Authors

Suresh Mickymaray

Faiz Abdulaziz Alfaiz

Anand Paramasivam

Affiliations

Soon will be listed here.

Abstract

Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents.

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