Expression of Metalloproteinases MMP-2 and MMP-9 is Associated to the Presence of Androgen Receptor in Epithelial Ovarian Tumors

Overview

Journal J Ovarian Res

Publisher Biomed Central

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2020 Jul 29

PMID 32718331

Citations 5

Authors

Flavia Morales-Vasquez

Rocio Castillo-Sanchez

Maria J Gomora

Miguel Angel Almaraz

Enrique Pedernera

Delia Perez-Montiel

Elizabeth Rendon

Horacio Noe Lopez-Basave

Edgar Roman-Basaure

Sergio Cuevas-Covarrubias

Juan Maldonado-Cubas

Antonio Villa

Carmen Mendez

Affiliations

Soon will be listed here.

Abstract

Background: The current study evaluated the metalloproteinases MMP-2 and MMP-9 expression in epithelial cells and the surrounding stroma in ovarian tumors and the association of MMPs with the histological subtypes, the clinical stage and the presence of steroid hormone receptors. Tumor samples were obtained from 88 patients undergoing surgical cytoreduction of primary ovarian tumors in Instituto Nacional de Cancerología, from México City. The formalin fixed and paraffin embedded samples were processed in order to demonstrate the presence of androgen receptor,estrogen receptor alpha, progesterone receptor, MMP-2,MMP-9 and collagen IV by immunohistochemistry and/or immunofluorescence.

Results: MMP-2 and MMP-9 were differentially expressed in the epithelium and the stroma of ovarian tumors associated to histological subtype, clinical stage and sexual steroid hormone receptor expression. Based on Cox proportional hazard regression model we demonstrated that MMP-2 located in the epithelium and the stroma are independent prognostic biomarkers for overall survival in epithelial ovarian tumors. Kaplan Meir analysis of the combination of AR (+) with MMP-2 (+) in epithelium and AR (+) with MMP-2 (-) in stroma displayed a significant reduction of survival.

Conclusions: The presence of MMP-2 in the stroma of the tumor was a protective factor while the presence of MMP-2 in the epithelium indicated an adverse prognosis. The presence of AR associated with MMP-2 in the tumor cells was a risk factor for overall survival in epithelial ovarian cancer.

Citing Articles

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Zhu D, Zhong H, Shi J, Liu Q, Wang Y Anal Bioanal Chem. 2025; .

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17β-hydroxysteroid dehydrogenase type 1 improves survival in serous epithelial ovarian tumors.

Pedernera E, Morales-Vasquez F, Gomora M, Almaraz M, Mena E, Perez-Montiel D Endocr Connect. 2023; 12(12).

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Utility of Matrix Metalloproteinases in the Diagnosis, Monitoring and Prognosis of Ovarian Cancer Patients.

Kicman A, Niczyporuk M, Kulesza M, Motyka J, Lawicki S Cancer Manag Res. 2022; 14:3359-3382.

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Molecular Regulation of Androgen Receptors in Major Female Reproductive System Cancers.

Wu S, Yu K, Lian Z, Deng S Int J Mol Sci. 2022; 23(14).

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The Impact of Matrix Metalloproteinase-11 Polymorphisms on Colorectal Cancer Progression and Clinicopathological Characteristics.

Huang H, Shiu B, Su S, Huang C, Ting W, Chang L Diagnostics (Basel). 2022; 12(7).

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