Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2010 Apr 8

PMID 20371345

Citations 2255

Authors

Kai Kessenbrock

Vicki Plaks

Zena Werb

Affiliations

Soon will be listed here.

Abstract

Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis. The matrix metalloproteinases (MMPs) represent the most prominent family of proteinases associated with tumorigenesis. Recent technological developments have markedly advanced our understanding of MMPs as modulators of the tumor microenvironment. In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner. These aspects of MMP function are reorienting our approaches to cancer therapy.

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