RNAi Suppressor: The Hidden Weapon of SARS-CoV

Overview

Journal J Biosci

Specialties Biochemistry
Biology

Date 2020 Jul 28

PMID 32713862

Citations 6

Authors

Sumona Karjee

Sunil Kumar Mukherjee

Affiliations

Soon will be listed here.

Abstract

The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. The following mini review addresses this question.

Citing Articles

Impact of the Transboundary Interference Inhibitor on RNAi and the Baculovirus Expression System in Insect Cells.

Zheng H, Zhao H, Xiong H, Awais M, Zeng S, Sun J Insects. 2024; 15(6).

PMID: 38921090 PMC: 11203448. DOI: 10.3390/insects15060375.

Anticipating the Next Chess Move: Blocking SARS-CoV-2 Replication and Simultaneously Disarming Viral Escape Mechanisms.

Casseb S, Khayat A, de Souza J, de Oliveira E, Dos Santos S, da Costa Vasconcelos P Genes (Basel). 2022; 13(11).

PMID: 36421821 PMC: 9690012. DOI: 10.3390/genes13112147.

Dysregulation of RNA interference components in COVID-19 patients.

Mousavi S, Sajjadi M, Khosravian F, Feizbakhshan S, Salmanizadeh S, Esfahani Z BMC Res Notes. 2021; 14(1):401.

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In silico analysis suggests the RNAi-enhancing antibiotic enoxacin as a potential inhibitor of SARS-CoV-2 infection.

Ahmadi A, Moradi S Sci Rep. 2021; 11(1):10271.

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MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak.

Jamalkhah M, Asaadi Y, Azangou-Khyavy M, Khanali J, Soleimani M, Kiani J J Transl Med. 2021; 19(1):164.

PMID: 33888147 PMC: 8061879. DOI: 10.1186/s12967-021-02840-3.

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