Maintaining Social Contacts: The Physiological Relevance of Organelle Interactions

Overview

Journal Biochim Biophys Acta Mol Cell Res

Publisher Elsevier

Specialties Biochemistry
Biophysics
Cell Biology

Date 2020 Jul 27

PMID 32712071

Citations 35

Authors

Beatriz S C Silva

Laura DiGiovanni

Rechal Kumar

Ruth E Carmichael

Peter K Kim

Michael Schrader

Affiliations

Soon will be listed here.

Abstract

Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed "membrane contact sites" (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment.

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References

Stoica R, De Vos K, Paillusson S, Mueller S, Sancho R, Lau K . ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nat Commun. 2014; 5:3996. PMC: 4046113. DOI: 10.1038/ncomms4996. View

Kornmann B . The endoplasmic reticulum-mitochondria encounter structure: coordinating lipid metabolism across membranes. Biol Chem. 2020; 401(6-7):811-820. DOI: 10.1515/hsz-2020-0102. View

Norambuena A, Wallrabe H, Cao R, Wang D, Silva A, Svindrych Z . A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. EMBO J. 2018; 37(22). PMC: 6236329. DOI: 10.15252/embj.2018100241. View

Wang P, Pleskot R, Zang J, Winkler J, Wang J, Yperman K . Plant AtEH/Pan1 proteins drive autophagosome formation at ER-PM contact sites with actin and endocytic machinery. Nat Commun. 2019; 10(1):5132. PMC: 6853982. DOI: 10.1038/s41467-019-12782-6. View

Westermann B . The mitochondria-plasma membrane contact site. Curr Opin Cell Biol. 2015; 35:1-6. DOI: 10.1016/j.ceb.2015.03.001. View

Ahumada-Castro U, Silva-Pavez E, Lovy A, Pardo E, Molgo J, Cardenas C . MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca communication: a dead end in cancer cells. Autophagy. 2018; 15(2):358-361. PMC: 6333456. DOI: 10.1080/15548627.2018.1537769. View

Wang H, Sreenivasan U, Gong D, OConnell K, Dabkowski E, Hecker P . Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction. J Lipid Res. 2013; 54(4):953-65. PMC: 3606001. DOI: 10.1194/jlr.M032466. View

Baixauli F, Acin-Perez R, Villarroya-Beltri C, Mazzeo C, Nunez-Andrade N, Gabande-Rodriguez E . Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses. Cell Metab. 2015; 22(3):485-98. PMC: 5026297. DOI: 10.1016/j.cmet.2015.07.020. View

Guimaraes S, Schuster M, Bielska E, Dagdas G, Kilaru S, Meadows B . Peroxisomes, lipid droplets, and endoplasmic reticulum "hitchhike" on motile early endosomes. J Cell Biol. 2015; 211(5):945-54. PMC: 4674278. DOI: 10.1083/jcb.201505086. View

10.

Marchi S, Patergnani S, Pinton P . The endoplasmic reticulum-mitochondria connection: one touch, multiple functions. Biochim Biophys Acta. 2013; 1837(4):461-9. DOI: 10.1016/j.bbabio.2013.10.015. View

11.

McLelland G, Soubannier V, Chen C, McBride H, Fon E . Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J. 2014; 33(4):282-95. PMC: 3989637. DOI: 10.1002/embj.201385902. View

12.

Wang H, Bell M, Sreenivasan U, Sreenevasan U, Hu H, Liu J . Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J Biol Chem. 2011; 286(18):15707-15. PMC: 3091179. DOI: 10.1074/jbc.M110.207779. View

13.

Gomez-Suaga P, Paillusson S, Stoica R, Noble W, Hanger D, Miller C . The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy. Curr Biol. 2017; 27(3):371-385. PMC: 5300905. DOI: 10.1016/j.cub.2016.12.038. View

14.

Frolov A, Zielinski S, Crowley J, Dudley-Rucker N, Schaffer J, Ory D . NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. J Biol Chem. 2003; 278(28):25517-25. DOI: 10.1074/jbc.M302588200. View

15.

Roca-Agujetas V, de Dios C, Leston L, Mari M, Morales A, Colell A . Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxid Med Cell Longev. 2019; 2019:3809308. PMC: 6875203. DOI: 10.1155/2019/3809308. View

16.

Parekh A . Slow feedback inhibition of calcium release-activated calcium current by calcium entry. J Biol Chem. 1998; 273(24):14925-32. DOI: 10.1074/jbc.273.24.14925. View

17.

Eberhart T, Kovacs W . Pexophagy in yeast and mammals: an update on mysteries. Histochem Cell Biol. 2018; 150(5):473-488. DOI: 10.1007/s00418-018-1724-3. View

18.

Wang Y, Metz J, Costello J, Passmore J, Schrader M, Schultz C . Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression. PLoS One. 2018; 13(12):e0209507. PMC: 6307868. DOI: 10.1371/journal.pone.0209507. View

19.

Lee K, Huh S, Lee S, Wu Z, Kim A, Kang H . Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models. Proc Natl Acad Sci U S A. 2018; 115(38):E8844-E8853. PMC: 6156612. DOI: 10.1073/pnas.1721136115. View

20.

Lawrie A, Rizzuto R, Pozzan T, Simpson A . A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells. J Biol Chem. 1996; 271(18):10753-9. DOI: 10.1074/jbc.271.18.10753. View